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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 376 - 384 (9page)
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Background and Purpose The rate of donepezil discontinuation and the underlying reasons for discontinuation in Asian patients with Alzheimer’s disease (AD) are currently unknown. We aimed to determine the treatment discontinuation rates in AD patients who had newly been prescribed donepezil in routine clinical practice in Asia. Methods This 1-year observational study involved 38 institutions in seven Asian countries, and it evaluated 398 participants aged 50?90 years with a diagnosis of probable AD and on newly prescribed donepezil monotherapy. The primary endpoint was the rate of donepezil discontinuation over 1 year. Secondary endpoints included the reason for discontinuation, treatment duration, changes in cognitive function over the 1-year study period, and compliance as assessed using a clinician rating scale (CRS) and visual analog scale (VAS). Results Donepezil was discontinued in 83 (20.9%) patients, most commonly due to an adverse event (43.4%). The mean treatment duration was 103.67 days in patients who discontinued. Among patients whose cognitive function was assessed at baseline and 1 year, there were no significant changes in scores on the Mini-Mental State Examination, Montreal Cognitive Assessment, and Trail-Making Test?Black and White scores, whereas the Clinical Dementia Rating score increased significantly (p<0.001). Treatment compliance at 1 year was 96.8% (306/316) on the CRS and 92.6±14.1% (mean±standard deviation) on the VAS. Conclusions In patients on newly prescribed donepezil, the primary reason for discontinuation was an adverse event. Cognitive assessments revealed no significant worsening at 1 year, indicating that continuous donepezil treatment contributes to the maintenance of cognitive function.
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참고문헌 (38)
참고문헌 신청
Kontis V / 2017 / Future life expectancy in 35 industrialised countries : projections with a Bayesian model ensemble / Lancet 389:1323~1335
World Health Organization / Dementia fact sheet
World Health Organization / 10 facts on dementia
Alzheimer’s Disease International / Alzheimer’s Australia. Dementia in the Asia Pacific Region
Rogers SL / 1998 / Donepezil improves cognition and global function in Alzheimer disease : a 15-week, double-blind, placebo-controlled study / Arch Intern Med 158:1021~1031
World Health Organization / Dementia fact sheet
World Health Organization / 10 facts on dementia
Alzheimer’s Disease International / Alzheimer’s Australia. Dementia in the Asia Pacific Region
Rogers SL / 1998 / Donepezil improves cognition and global function in Alzheimer disease : a 15-week, double-blind, placebo-controlled study / Arch Intern Med 158:1021~1031
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