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학술저널
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Yi Yuan Tan (Department of Gastroenterology and Hepatology Changi General Hospital Singapore Singapore) Gary Sei Kiat Tay (Department of Pathology Changi General Hospital Singapore Singapore) Yu Jun Wong (Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore) James Weiquan Li (Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore) Andrew Boon Eu Kwek (Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore) Tiing Leong Ang (Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore) Lai Mun Wang (Pathology Academic Clinical Programme SingHealth Duke-NUS Medical School Singapore Singapore) Malcolm Teck Kiang Tan (Department of Gastroenterology and Hepatology Changi General Hospital Singapore Singapore)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제4호
발행연도
2021.1
수록면
578 - 588 (11page)

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Background/Aims: Proximal colorectal cancers (CRCs) account for up to half of CRCs. Sessile serrated lesions (SSLs) are precursorsto CRC. Proximal location and presence of dysplasia in SSLs predict higher risks of progression to cancer. The prevalence of dysplasiain proximal SSLs (pSSLs) and clinical characteristics of dysplastic pSSLs are not well studied. Methods: Endoscopically resected colonic polyps at our center between January 2016 and December 2017 were screened for pSSLs. Data of patients with at least one pSSL were retrieved and clinicopathological features of pSSLs were analysed. pSSLs with andwithout dysplasia were compared for associations. Results: Ninety pSSLs were identified, 45 of which had dysplasia giving a prevalence of 50.0%. Older age (65.9 years vs. 60.1 years,p=0.034) was associated with the presence of dysplasia. Twelve pSSLs were 10 mm or larger. After adjusting for age, pSSLs ≥10 mmhad an adjusted odds ratio of 5.98 (95% confidence interval, 1.21?29.6) of having dysplasia compared with smaller pSSLs. Conclusions: In our cohort of pSSLs, the prevalence of dysplasia is high at 50.0% and is associated with lesion size ≥10 mm. Endoscopic resection for all proximal serrated lesions should be en-bloc to facilitate accurate histopathological examination fordysplasia as its presence warrants shorter surveillance intervals.

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