지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 582 - 589 (8page)
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초록· 키워드
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Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in the serrated pathway that may account for at least 15% of all tumors. The serrated pathway is distinct from the two other CRC pathways and involves an epigenetic hypermethyl-ation mechanism of CpG islands within promoter regions of tumor suppressor genes. This process results in the forma-tion of CpG island methylator phenotype tumors. Serrated polyps are divided into hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adeno-mas (TSAs). The SSA/P and the TSA have the potential for dysplasia and subsequent malignant transformation. The SSA/Ps are more common and are more likely to be flat than TSAs. Their flat morphology may make them difficult to de-tect and thus explain the variation in detection rates among endoscopists. Challenges for endoscopists also include the difficulty in pathological interpretation as well surveillance of these lesions. Furthermore, serrated polyps may be inad-equately resected by endoscopists. Thus, it is not surprising that the serrated pathway has been linked with interval can-cers. This review will provide the physician or clinician with the knowledge to manage patients with serrated polyps.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] -
Anderson JC / 2000 / Predicting of hyperplastic histology by endoscopic features / Gastrointest Endosc 52 : 149 ~ 150
Anderson JC / 2003 / Prevalence of colorectal neoplasia in smokers / Am J Gastroenterol 98 : 2777 ~ 2783
Anderson JC / 2009 / Smokers as a highrisk group: data from a screening population / J Clin Gastroenterol 43 : 747 ~ 752
Anderson JC / 2010 / Increased frequency of serrated aberrant crypt foci among smokers / Am J Gastroenterol 105 : 1648 ~ 1654
Anderson JC / 2000 / Predicting of hyperplastic histology by endoscopic features / Gastrointest Endosc 52 : 149 ~ 150
Anderson JC / 2003 / Prevalence of colorectal neoplasia in smokers / Am J Gastroenterol 98 : 2777 ~ 2783
Anderson JC / 2009 / Smokers as a highrisk group: data from a screening population / J Clin Gastroenterol 43 : 747 ~ 752
Anderson JC / 2010 / Increased frequency of serrated aberrant crypt foci among smokers / Am J Gastroenterol 105 : 1648 ~ 1654
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