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논문 기본 정보

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학술저널
저자정보
Umair Iqbal (Department of Gastroenterology and Hepatology Geisinger Medical Center Danville PA USA) Hafsa Anwar (Department of Internal Medicine Capital Health Regional Medical Center Trenton NJ USA) Hafiz Umair Siddiqui (Department of Surgery Cleveland Clinic Foundation Cleveland OH USA) Muhammad Ali Khan (Department of Gastroenterology and Hepatology The University of Texas TX USA) Faisal Kamal (Department of Gastroenterology University of Tennessee at Memphis Health Sciences Center) Bradley D. Confer (Department of Gastroenterology and Hepatology Geisinger Medical Center Danville PA USA) Harshit S. Khara (Department of Gastroenterology and Hepatology Geisinger Medical Center Danville PA USA)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제4호
발행연도
2021.1
수록면
534 - 541 (8page)

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Background/Aims: More than 100 million people to date have been affected by the coronavirus disease-2019 (COVID-19)pandemic. Patients with COVID-19 have a higher risk of bleeding complications. We performed a systematic review and metaanalysisto evaluate the outcomes of COVID-19 patients with signs and symptoms of acute gastrointestinal bleeding (GIB). Methods: A systematic literature search was carried out for articles published until until November 11, 2020, in the Embase,MEDLINE, Web of Science, and Cochrane Library databases. We included studies on COVID-19 patients with signs and symptomsof GIB. Results: Our search yielded 49 studies, of which eight with a collective 127 patients (86 males and 41 females) met our inclusioncriteria. Conservative management alone was performed in 59% of the patients, endoscopic evaluation in 31.5%, and interventionalradiology (IR) embolization in 11%. Peptic ulcer disease was the most common endoscopic finding, diagnosed in 47.5% of thepatients. Pooled overall mortality was 19.1% (95% confidence interval [CI]; 12.7%-27.6%) and pooled mortality secondary to GIBwas 3.5% (95% CI; 1.3%?9.1%). The pooled risk of rebleeding was 11.3% (95% CI; 6.8%?18.4%). Conclusions: The majority of COVID-19 patients with GIB responded to conservative management, with a low mortalityrate associated with GIB and the risk of rebleeding. Thus, we suggest limiting endoscopic and IR interventions to those withhemodynamic instability and those for whom conservative management was unsuccessful.

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