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논문 기본 정보

자료유형
학술저널
저자정보
Kazuya Inoki (Division of Gastroenterology Department of Medicine Showa University School of Medicine Tokyo Japan) Seiichiro Abe (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Yusaku Tanaka (Department of Gastroenterology Keiyu Hospital Kanagawa Japan) Koji Yamamoto (Department of Gastroenterology Arao Municipal Hospital Kumamoto Japan) Daisuke Hihara (Division of Gastroenterology and Hepatology Toho University Medical Center Ohashi Hospital Tokyo) Ryoji Ichijima (Division of Gastroenterology and Hepatology Nihon University School of Medicine Tokyo Japan) Yukihiro Nakatani (Department of Gastroenterology Chofu Touzan Hospital Tokyo Japan) Hsin- Yu Chen (Division of Gastroenterology Cathay General Hospital Taipei Taiwan) Hiroyuki Takamaru (Divisions of Endoscopy National Cancer Center Hospital Tokyo Japan) Masau Sekiguchi (Cancer Screening Center National Cancer Center Hospital Tokyo Japan) Masayoshi Yamada (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Taku Sakamoto (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Satoru Nonaka (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Haruhisa Suzuki (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Shigetaka Yoshinaga (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Ichiro Oda (Endoscopy Division National Cancer Center Hospital Tokyo Japan) Takahisa Matsuda (Cancer Screening Center National Cancer Center Hospital Tokyo Japan) Yutaka Saito (Endoscopy Division National Cancer Center Hospital Tokyo Japan)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy 제54권 제3호
발행연도
2021.1
수록면
363 - 370 (8page)

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Background/Aims: Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE. Methods: Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in thestudy. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination ofthe optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by threeendoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were notdeemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated. Results: A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLEwith IV fluorescein at 0.5 mg/kg. Conclusions: In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both theupper and lower GI tract.
#Duodenum #Endoscopy #Fluorescein #Lower gastrointestinal tract #Stomach

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참고문헌 (32)

참고문헌 신청
Wallace MB / 2009 / Probe-based confocal laser endomicroscopy / Gastroenterology 136:1509~1513 google schola Sharma P / 2011 / Real-time increased detection of neoplastic tissue in Barrett’s esophagus with probe-based confocal laser endomicroscopy : final results of an international multicenter, prospective, randomized, controlled trial / Gastrointest Endosc 74:465~472 google schola Park JC / 2017 / Probe-based confocal laser endomicroscopy in the margin delineation of early gastric cancer for endoscopic submucosal dissection / J Gastroenterol Hepatol 32:1046~1054 google schola Kim B / 2017 / Probe-based confocal laser endomicroscopy for evaluating the submucosal invasion of colorectal neoplasms / Surg Endosc 31:594~601 google schola Abe S / 2018 / Pilot study on probe-based confocal laser endomicroscopy for colorectal neoplasms : an initial experience in Japan / Int J Colorectal Dis 33:1071~1078 google schola

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