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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 197 - 203 (7page)
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초록· 키워드
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Mesenchymal stem cells in the dental pulp exhibit a tendency for differentiation into various dental lineages and holdgreat potential as a major conduit for regenerative treatment in dentistry. Although they can be readily isolated fromteeth, the exact characteristics of these stem cells have not been fully understood so far. When compared to twodimensional(2D) cultures, three-dimensional (3D) cultures have the advantage of enriching the stem cell population. Hence, 3D-organoid culture and 3D-sphere culture were applied to dental pulp cells in the current study. Althoughthe establishment of the organoid culture proved unsuccessful, the 3D-sphere culture readily initiated the stablegeneration of cell aggregates, which continued to grow and could be passaged to the second round. Interestingly, asignificant increase in SOX2 expression was detected in the 3D-spheroid culture compared to the 2D culture. Theseresults indicate the enrichment of the stemness-high population in the 3D-sphere culture. Thus, 3D-sphere culturemay act as a link between the conventional and 3D-organoid cultures and aid in understanding the characteristics ofdental pulp stem cells.
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참고문헌 (23)
참고문헌 신청
César Nombela-Arrieta / 2011 / The elusive nature and function of mesenchymal stem cells / Nature Reviews Molecular Cell Biology 12(2):126~131
M. F. Pittenger / 1999 / Multilineage Potential of Adult Human Mesenchymal Stem Cells / Science 284(5411):143~147
Antonio Uccelli / 2008 / Mesenchymal stem cells in health and disease / Nature Reviews Immunology 8(9):726~736
Paul T. Sharpe / 2016 / Dental mesenchymal stem cells / Development 143(13):2273~2280
Junjun Liu / 2015 / Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells / STEM CELLS 33(3):627~638
M. F. Pittenger / 1999 / Multilineage Potential of Adult Human Mesenchymal Stem Cells / Science 284(5411):143~147
Antonio Uccelli / 2008 / Mesenchymal stem cells in health and disease / Nature Reviews Immunology 8(9):726~736
Paul T. Sharpe / 2016 / Dental mesenchymal stem cells / Development 143(13):2273~2280
Junjun Liu / 2015 / Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells / STEM CELLS 33(3):627~638
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