Clinical Characteristics and Causative Pathogens of Infective Arthritis and Risk Factors for Gram-Negative Bacterial Infections

Lee Yongseop; Cho Yun Suk; Sohn Yu Jin; Hyun Jong Hoon; Ahn Sang Min; Lee Woon Ji; Kim Jung Ho; Seong Hye; Kim Junhyoung; Jeong Su Jin; Ku Nam Su; Yeom Joon Sup; Ahn Jin Young; Choi Jun Yong

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자료유형: 학술저널

저자정보: Lee Yongseop (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Cho Yun Suk (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Sohn Yu Jin (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Hyun Jong Hoon (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Ahn Sang Min (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Lee Woon Ji (Yonsei University College of Medicine) Kim Jung Ho (Yonsei University College of Medicine) Seong Hye (Yonsei University College of Medicine) Kim Junhyoung (Yonsei University College of Medicine) Jeong Su Jin (Yonsei University College of Medicine) Ku Nam Su (Yonsei University College of Medicine) Yeom Joon Sup (Yonsei University College of Medicine) Ahn Jin Young (Yonsei University College of Medicine) Choi Jun Yong (Yonsei University College of Medicine)

저널정보: 대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제52권 제4호

발행연도: 2020.1

수록면: 503 - 515 (13page)

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Background: The aim of this study was to describe the clinical and microbiological characteristics of infective arthritis and to analyze risk factors for Gram-negative bacterial infections that cause infective arthritis. Materials and Methods: Patients admitted between 2009 - 2018 with infective arthritis in a single-tertiary hospital were evaluated retrospectively. Results: A total of 181 patients were enrolled in this study. Of them, 135 were native joint infection patients and 46 were prosthetic joint infection patients. The most common site of infective arthritis was the knee (63.6%), followed by the shoulder (17.7%), and the hip (9.9%). The most frequently identified microorganisms were Staphylococcus aureus (51.1%), followed by Streptococci sp. (21.1%), Enterobacteriaceae (8.4%), and coagulase-negative-Staphylococci (CNS; 8.4%). Infections due to Gram-negative bacteria and fungi made up 13.7% and 3.2% of all cases, respectively. Additionally, 20% and 4.2% of the cases involved methicillin-resistant S. aureus (MRSA) and MRCNS. We found that bacteriuria, infective arthritis in the hip, and steroid use at admission are independent risk factors for Gram-negative bacterial infections. Conclusion: Infective arthritis with methicillin-resistant microorganisms reached up to about 25% in a single-tertiary hospital in Korea. In case of suspected urinary tract infection, infective arthritis of the hip joint, or steroid use at admission time among infective arthritis patients, empirical treatment covering Gram-negative microorganisms can be considered.

#Arthritis #infectious #Gram-negative bacterial infections #Methicillin resistance #Risk factors

참고문헌 (20)

참고문헌 신청

Gupta MN / 2001 / A prospective 2-year study of 75 patients with adult-onset septic arthritis / Rheumatology(Oxford) 40:24~30

Le Dantec L / 1996 / Peripheral pyogenic arthritis. A study of one hundred seventy-nine cases / Rev Rhum Engl Ed 63:103~110

Morgan DS / 1996 / An 18 year clinical review of septic arthritis from tropical Australia / Epidemiol Infect 117:423~428

Ryan MJ / 1997 / Bacterial joint infections in England and Wales : analysis of bacterial isolates over a four year period / Br J Rheumatol 36:370~373

Seo SS / 2008 / Etiologic transition of septic arthritis of the knee / J Korean Knee Soc 20:44~49

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