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논문 기본 정보
- 자료유형
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제2호
- 발행연도
- 2021.1
- 수록면
- 226 - 232 (7page)
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초록· 키워드
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Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging phlebovirus of the Phenuiviridae family that has been circulating in the following Asian countries: Vietnam, Myanmar, Taiwan, China, Japan, and South Korea. Despite the increasing infection rates and relatively high mortality rate, there is limited information available regarding SFTSV pathogenesis. In addition, there are currently no vaccines or effective antiviral treatments available. Previous reports have shown that SFTSV suppresses the host immune response and its nonstructural proteins (NSs) function as an antagonist of type I interferon (IFN), whose induction is an essential part of the host defense system against viral infections. Given that SFTSV NSs suppress the innate immune response by inhibiting type I IFN, we investigated the mechanism utilized by SFTSV NSs to evade IFNmediated response. Our co-immunoprecipitation data suggest the interactions between NSs and retinoic acid inducible gene-I (RIG-I) or TANK binding kinase 1 (TBK1). Furthermore, confocal analysis indicates the ability of NSs to sequester RIG-I and related downstream molecules in the cytoplasmic structures called inclusion bodies (IBs). NSs are also capable of inhibiting TBK1- interferon regulatory factor 3 (IRF3) interaction, and therefore prevent the phosphorylation and nuclear translocation of IRF3 for the induction of type I IFN. The ability of SFTSV NSs to interact with and sequester TBK1 and IRF3 in IBs demonstrate an effective yet unique method utilized by SFTSV to evade and suppress host immunity.
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참고문헌 (45)
참고문헌 신청
Tran XC / 2019 / Endemic severe fever with thrombocytopenia syndrome, Vietnam / Emerg. Infect. Dis 25:1029~1031
Win AM / 2020 / Genotypic heterogeneity of Orientia tsutsugamushi in scrub typhus patients and thrombocytopenia syndrome co-infection, Myanmar / Emerg. Infect. Dis 26:1878~1881
Lin T-L / 2020 / The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan / Emerg. Microb. Infect 9:148~151
Kim K-H / 2013 / Severe fever with thrombocytopenia syndrome, South Korea, 2012 / Emerg. Infect. Dis 19:1892~1894
Zhang Y-Z / 2012 / The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China / J. Virol 86:2864~2868
Win AM / 2020 / Genotypic heterogeneity of Orientia tsutsugamushi in scrub typhus patients and thrombocytopenia syndrome co-infection, Myanmar / Emerg. Infect. Dis 26:1878~1881
Lin T-L / 2020 / The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan / Emerg. Microb. Infect 9:148~151
Kim K-H / 2013 / Severe fever with thrombocytopenia syndrome, South Korea, 2012 / Emerg. Infect. Dis 19:1892~1894
Zhang Y-Z / 2012 / The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China / J. Virol 86:2864~2868
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