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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제12호
- 발행연도
- 2019.1
- 수록면
- 1,873 - 1,881 (9page)
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초록· 키워드
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The innate immune response serves as a first-line-of-defense mechanism for a host against viral infection. Viruses must therefore subvert this anti-viral response in order to establish an efficient life cycle. In line with this fact, Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes numerous genes that function as immunomodulatory proteins to antagonize the host immune system. One such mechanism through which KSHV evades the host immunity is by encoding a viral homolog of cellular interferon (IFN) regulatory factors (IRFs), known as vIRFs. Herein, we summarize recent advances in the study of the immunomodulatory strategies of KSHV vIRFs and their effects on KSHV-associated pathogenesis.
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참고문헌 (55)
참고문헌 신청
Soulier J / 1995 / Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease / Blood 86:1276~1280
Nador RG / 1996 / Primary effusion lymphoma : a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus / Blood 88:645~656
Ganem D / 2010 / KSHV and the pathogenesis of Kaposi sarcoma : listening to human biology and medicine / J. Clin. Invest 120:939~949
Lee HR / 2015 / Multi-step regulation of innate immune signaling by Kaposi’s sarcoma-associated herpesvirus / Virus Res 209:39~44
Li M / 1998 / Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor / J. Virol 72:5433~5440
Nador RG / 1996 / Primary effusion lymphoma : a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus / Blood 88:645~656
Ganem D / 2010 / KSHV and the pathogenesis of Kaposi sarcoma : listening to human biology and medicine / J. Clin. Invest 120:939~949
Lee HR / 2015 / Multi-step regulation of innate immune signaling by Kaposi’s sarcoma-associated herpesvirus / Virus Res 209:39~44
Li M / 1998 / Kaposi’s sarcoma-associated herpesvirus viral interferon regulatory factor / J. Virol 72:5433~5440
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