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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제2호
- 발행연도
- 2021.1
- 수록면
- 189 - 196 (8page)
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Periplanetasin-2 from cockroach exhibits broad-spectrum antimicrobial activity. The underlying antibacterial mechanisms rely on the stimulation of reactive oxygen species overproduction to induce apoptotic cell death. A promising strategy to increase the bioavailability of periplanetasin-2 involves reducing the dose through combination therapy with other antibacterials that show synergistic effects. Thus, the synergistic antibacterial activity of periplanetasin-2 with conventional antibacterial agents and its mechanisms was examined against Escherichia coli in this study. Among the agents tested, the combinations of periplanetasin-2 with vancomycin and chloramphenicol exhibited synergistic effects. Periplanetasin-2 in combination with vancomycin and chloramphenicol demonstrated antibacterial activity through the intracellular oxidative stress response. The combination with vancomycin resulted in the enhancement of bacterial apoptosislike death, whereas the combination with chloramphenicol enhanced oxidative stress damage. These synergistic interactions of periplanetasin-2 can help broaden the spectrum of conventional antibiotics. The combination of antimicrobial peptides and conventional antibiotics is proposed as a novel perspective on treatments to combat severe bacterial infection.
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참고문헌 (35)
참고문헌 신청
Bassetti M / 2015 / New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections / Cur. Opin. Critic. Care 21:402~411
Wang S / 2016 / Antimicrobial peptides as potential alternatives to antibiotics in food animal industry / Int. J. Mol. Sci 17:603
Chan EWL / 2017 / Synergistic effect of non-steroidal anti-inflammatory drugs(NSAIDs)on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus / J. Glob Antimicrob. Resist 10:70~74
Starr CG / 2016 / Host cell interactions are a significant barrier to the clinical utility of peptide antibiotics / ACS Chem. Biol 11:3391~3399
Tamma PD / 2012 / Combination therapy for treatment of infections with gram-negative bacteria / Clin. Microbiol. Rev 25:450~470
Wang S / 2016 / Antimicrobial peptides as potential alternatives to antibiotics in food animal industry / Int. J. Mol. Sci 17:603
Chan EWL / 2017 / Synergistic effect of non-steroidal anti-inflammatory drugs(NSAIDs)on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus / J. Glob Antimicrob. Resist 10:70~74
Starr CG / 2016 / Host cell interactions are a significant barrier to the clinical utility of peptide antibiotics / ACS Chem. Biol 11:3391~3399
Tamma PD / 2012 / Combination therapy for treatment of infections with gram-negative bacteria / Clin. Microbiol. Rev 25:450~470
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