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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 408 - 421 (14page)
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초록· 키워드
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The outbreak of coronavirus disease 2019 (COVID-19) has not only affected human health but also diverted the focus of research and derailed the world economy over the past year. Recently, vaccination against COVID-19 has begun, but further studies on effective therapeutic agents are still needed. The severity of COVID-19 is attributable to several factors such as the dysfunctional host immune response manifested by uncontrolled viral replication, type I interferon suppression, and release of impaired cytokines by the infected resident and recruited cells. Due to the evolving pathophysiology and direct involvement of the host immune system in COVID-19, the use of immune-modulating drugs is still challenging. For the use of immune-modulating drugs in severe COVID-19, it is important to balance the fight between the aggravated immune system and suppression of immune defense against the virus that causes secondary infection. In addition, the interplaying events that occur during virus?host interactions, such as activation of the host immune system, immune evasion mechanism of the virus, and manifestation of different stages of COVID-19, are disjunctive and require thorough streamlining. This review provides an update on the immunotherapeutic interventions implemented to combat COVID-19 along with the understanding of molecular aspects of the immune evasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may provide opportunities to develop more effective and promising therapeutics.
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참고문헌 (91)
참고문헌 신청
Acharya, D. / 2020 / Dysregulation of type I interferon responses in COVID-19 / Nat. Rev. Immunol 20:397~398
Arabi, Y. M. / 2018 / Corticosteroid therapy for critically ill patients with Middle East Respiratory Syndrome / Am. J. Respir. Crit. Care Med 197:757~767
Beigel, J. H. / 2020 / Remdesivir for the treatment of Covid-19 - final report / N. Engl. J. Med 383:1813~1826
Blanco-Melo, D. / 2020 / Imbalanced host response to SARS-CoV-2 drives development of COVID-19 / Cell 181:1036~1045
Bonanad, C. / 2020 / The effect of age on mortality in patients with COVID-19: a metaanalysis with 611,583 subjects / J. Am. Med. Dir. Assoc 21:915~918
Arabi, Y. M. / 2018 / Corticosteroid therapy for critically ill patients with Middle East Respiratory Syndrome / Am. J. Respir. Crit. Care Med 197:757~767
Beigel, J. H. / 2020 / Remdesivir for the treatment of Covid-19 - final report / N. Engl. J. Med 383:1813~1826
Blanco-Melo, D. / 2020 / Imbalanced host response to SARS-CoV-2 drives development of COVID-19 / Cell 181:1036~1045
Bonanad, C. / 2020 / The effect of age on mortality in patients with COVID-19: a metaanalysis with 611,583 subjects / J. Am. Med. Dir. Assoc 21:915~918
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