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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 328 - 334 (7page)
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The advent of the major histocompatibility complex (MHC) multimer technology has led to a breakthrough in the quantification and analysis of antigen-specific T cells. In particular, this technology has dramatically advanced the measurement and analysis of CD8 T cells and is being applied more widely. In addition, the scope of application of MHC multimer technology is gradually expanding to other T cells such as CD4 T cells, natural killer T cells, and mucosalassociated invariant T cells. MHC multimer technology acts by complementing the T-cell receptor-MHC/peptide complex affinity, which is relatively low compared to antigen-antibody affinity, through a multivalent interaction. The application of MHC multimer technology has expanded to include various functions such as quantification and analysis of antigen-specific T cells, cell sorting, depletion, stimulation to replace antigen-presenting cells, and single-cell classification through DNA barcodes. This review aims to provide the latest knowledge of MHC multimer technology, which is constantly evolving, broaden understanding of this technology, and promote its widespread use.
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참고문헌 (48)
참고문헌 신청
Altman, J. D. / 2003 / MHC-peptide tetramers to visualize antigen-specific T cells / Curr. Protoc. Immunol 53:17.3.1~17.3.33
Altman, J. D. / 1996 / Phenotypic analysis of antigen-specific T lymphocytes / Science 274:94~96
Bandura, D. R. / 2009 / Mass cytometry:technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry / Anal. Chem. 81:6813~6822
Bendall, S. C. / 2011 / Singlecell mass cytometry of differential immune and drug responses across a human hematopoietic continuum / Science 332:687~696
Bentzen, A. K. / 2016 / Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes / Nat. Biotechnol 34:1037~1045
Altman, J. D. / 1996 / Phenotypic analysis of antigen-specific T lymphocytes / Science 274:94~96
Bandura, D. R. / 2009 / Mass cytometry:technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry / Anal. Chem. 81:6813~6822
Bendall, S. C. / 2011 / Singlecell mass cytometry of differential immune and drug responses across a human hematopoietic continuum / Science 332:687~696
Bentzen, A. K. / 2016 / Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes / Nat. Biotechnol 34:1037~1045
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