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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 195 - 201 (7page)
- DOI
- 10.14348/molcells.2015.2331
이용수
초록· 키워드
오류제보하기
Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases.
In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.
목차
등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Allen, C. D. / 2007 / Imaging of germinal center selection events during affinity maturation / Science 315:528~531
Arnold, C. N. / 2007 / The germinal center response is impaired in the absence of T cell-expressed CXCR5 / Eur. J. Immunol 37:100~109
Ballesteros-Tato, A. / 2012 / Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation / Immunity 36:847~856
Baumjohann, D. / 2011 / Cutting edge : distinct waves of BCL6 expression during T follicular helper cell development / J. Immunol 187:2089~2092
Bentebibel, S. E. / 2013 / Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination / Sci. Transl. Med 5:176~232
Arnold, C. N. / 2007 / The germinal center response is impaired in the absence of T cell-expressed CXCR5 / Eur. J. Immunol 37:100~109
Ballesteros-Tato, A. / 2012 / Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation / Immunity 36:847~856
Baumjohann, D. / 2011 / Cutting edge : distinct waves of BCL6 expression during T follicular helper cell development / J. Immunol 187:2089~2092
Bentebibel, S. E. / 2013 / Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination / Sci. Transl. Med 5:176~232
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