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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 821 - 827 (7page)
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초록· 키워드
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Aging is the most important single risk factor for many chronic diseases such as cancer, metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might, therefore, be a better strategy than targeting each chronic disease individually for enhancing human health. Although much should be achieved for completely understanding the biological basis of aging, cellular senescence is now believed to mainly contribute to organismal aging via two independent, yet not mutually exclusive mechanisms: on the one hand, senescence of stem cells leads to exhaustion of stem cells and thus decreases tissue regeneration. On the other hand, senescent cells secrete many proinflammatory cytokines, chemokines, growth factors, and proteases, collectively termed as the senescence-associated secretory phenotype (SASP), which causes chronic inflammation and tissue dysfunction. Much effort has been recently made to therapeutically target detrimental effects of cellular senescence including selectively eliminating senescent cells (senolytics) and modulating a proinflammatory senescent secretome (senostatics). Here, we discuss current progress and limitations in understanding molecular mechanisms of senolytics and senostatics and therapeutic strategies for applying them. Furthermore, we propose how these novel interventions for aging treatment could be improved, based on lessons learned from cancer treatment.
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참고문헌 (63)
참고문헌 신청
Acosta, J. C. / 2013 / A complex secretory program orchestrated by the inflammasome controls paracrine senescence / Nat. Cell Biol 15:978~990
Acosta, J. C. / 2008 / Chemokine signaling via the CXCR2 receptor reinforces senescence / Cell 133:1006~1018
Al-Lazikani, B. / 2012 / Combinatorial drug therapy for cancer in the post-genomic era / Nat. Biotechnol 30:679~692
Baar, M. P. / 2017 / Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging / Cell 169:132~147
e16. Baker, D. J. / 2016 / Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan / Nature 530:184~189
Acosta, J. C. / 2008 / Chemokine signaling via the CXCR2 receptor reinforces senescence / Cell 133:1006~1018
Al-Lazikani, B. / 2012 / Combinatorial drug therapy for cancer in the post-genomic era / Nat. Biotechnol 30:679~692
Baar, M. P. / 2017 / Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging / Cell 169:132~147
e16. Baker, D. J. / 2016 / Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan / Nature 530:184~189
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