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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 68 - 78 (11page)
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Secondary metabolites enable plants to protect themselves from herbivorous insects. Among these, cucurbitacin B (cuc-B) is a bitter-tasting compound with promising pharmacological potential. Dietary exposure to cuc-B lowered the hemolymph glucose levels of Drosophila melanogaster fed with a high carbohydrate diet, which is homologous to high blood glucose in humans, and its effect was comparable to that of metformin, a well-known glucose-lowering drug. Furthermore, cuc-B reduced tissue sugar levels and glycogen levels, as well as triacylglycerol levels. Our results thus highlight the potential applicability of this compound to treat chronic metabolic diseases such as diabetes and obesity. Additionally, we analyzed sleep quality and taste-associative memory enhancement after cuc-B and metformin treatment. Both supplements increased nighttime bout length and metformin increased memory consolidation. Therefore, discarded shell of Cucurbitaceae could be processed into health supplements.
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참고문헌 (48)
참고문헌 신청
Adeyemi, M. H / 2010 / The potential of secondary metabolites in plant material as deterents against insect pests: a review / Afr. J. Pure Appl. Chem 4:243~246
Bailey, C. J. / 2017 / Metformin: historical overview / Diabetologia 60:1566~1576
Campbell, S. S. / 1984 / Animal sleep: a review of sleep duration across phylogeny / Neurosci. Biobehav. Rev 8:269~300
Catterson, J. H. / 2010 / Dietary modulation of Drosophila sleep-wake behaviour / PLoS One 5:e12062
Chen, J. C. / 2005 / Cucurbitacins and cucurbitane glycosides: structures and biological activities / Nat. Prod. Rep 22:386~399
Bailey, C. J. / 2017 / Metformin: historical overview / Diabetologia 60:1566~1576
Campbell, S. S. / 1984 / Animal sleep: a review of sleep duration across phylogeny / Neurosci. Biobehav. Rev 8:269~300
Catterson, J. H. / 2010 / Dietary modulation of Drosophila sleep-wake behaviour / PLoS One 5:e12062
Chen, J. C. / 2005 / Cucurbitacins and cucurbitane glycosides: structures and biological activities / Nat. Prod. Rep 22:386~399
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