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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 530 - 538 (9page)
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The Gustatory system enables animals to detect toxic bitter chemicals, which is critical for insects to survive food induced toxicity. Cucurbitacin is widely present in plants such as cucumber and gourds that acts as an anti-herbivore chemical and an insecticide. Cucurbitacin has a harmful effect on insect larvae as well. Although various beneficial effects of cucurbitacin such as alleviating hyperglycemia have also been documented, it is not clear what kinds of molecular sensors are required to detect cucurbitacin in nature. Cucurbitacin B, a major bitter component of bitter melon, was applied to induce action potentials from sensilla of a mouth part of the fly, labellum. Here we identify that only Gr33a is required for activating bitter-sensing gustatory receptor neurons by cucurbitacin B among available 26 Grs, 23 Irs, 11 Trp mutants, and 26 Gr-RNAi lines. We further investigated the difference between control and Gr33a mutant by analyzing binary food choice assay. We also measured toxic effect of Cucurbitacin B over 0.01 mM range. Our findings uncover the molecular sensor of cucurbitacin B in Drosophila melanogaster. We propose that the discarded shell of Cucurbitaceae can be developed to make a new insecticide.
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참고문헌 (50)
참고문헌 신청
Adeyemi, M. H / 2010 / The potential of secondary metabolites in plant material as deterents against insect pests : a review / Afr. J. Pure Appl. Chem 4:243~246
Akitake, B. / 2015 / Coordination and fine motor control depend on Drosophila TRPγ / Nat Commun 6:7288
Chen, J. C. / 2005 / Cucurbitacins and cucurbitane glycosides : structures and biological activities / Nat. Prod. Rep 22:386~399
Chyb, S. / 2003 / Drosophila Gr5a encodes a taste receptor tuned to trehalose / Proc. Natl. Acad. Sci. U. S. A 100:14526~14530
Clyne, P. J. / 2000 / Candidate taste receptors in Drosophila / Science 287:1830~1834
Akitake, B. / 2015 / Coordination and fine motor control depend on Drosophila TRPγ / Nat Commun 6:7288
Chen, J. C. / 2005 / Cucurbitacins and cucurbitane glycosides : structures and biological activities / Nat. Prod. Rep 22:386~399
Chyb, S. / 2003 / Drosophila Gr5a encodes a taste receptor tuned to trehalose / Proc. Natl. Acad. Sci. U. S. A 100:14526~14530
Clyne, P. J. / 2000 / Candidate taste receptors in Drosophila / Science 287:1830~1834
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