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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 671 - 685 (15page)
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The regulator of calcineurin (RCAN) was first reported as a novel gene called DSCR1, encoded in a region termed the Down syndrome critical region (DSCR) of human chromosome 21. Genome sequence comparisons across species using bioinformatics revealed three members of the RCAN gene family, RCAN1, RCAN2, and RCAN3, present in most jawed vertebrates, with one member observed in most invertebrates and fungi. RCAN is most highly expressed in brain and striated muscles, but expression has been reported in many other tissues, as well, including the heart and kidneys. Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca2+, amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer’s disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. RCAN binding to calcineurin, a Ca2+/calmodulin-dependent phosphatase, inhibits calcineurin activity, thereby regulating different physiological events via dephosphorylation of important substrates. Novel functions of RCANs have recently emerged, indicating involvement in mitochondria homeostasis, RNA binding, circadian rhythms, obesity, and thermogenesis, some of which are calcineurin-independent. These developments suggest that besides significant contributions to DS pathologies and calcineurin regulation, RCAN is an important participant across physiological systems, suggesting it as a favorable therapeutic target.
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참고문헌 (139)
참고문헌 신청
Antonarakis, S. E / 2017 / Down syndrome and the complexity of genome dosage imbalance / Nat. Rev. Genet 18:147~163
Antonarakis, S. E. / 2004 / Chromosome 21 and Down syndrome : from genomics to pathophysiology / Nat. Rev. Genet 5:725~738
Bassett, J. H. D. / 2012 / Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function / Endocrinology 153:3537~3548
Bouret, S. / 2015 / Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity / Physiol. Rev 95:47~82
Bray, M. S. / 2008 / Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression / Am. J. Physiol. Heart. Circ. Physiol 294:H1036~H1047
Antonarakis, S. E. / 2004 / Chromosome 21 and Down syndrome : from genomics to pathophysiology / Nat. Rev. Genet 5:725~738
Bassett, J. H. D. / 2012 / Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function / Endocrinology 153:3537~3548
Bouret, S. / 2015 / Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity / Physiol. Rev 95:47~82
Bray, M. S. / 2008 / Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression / Am. J. Physiol. Heart. Circ. Physiol 294:H1036~H1047
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