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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 368 - 373 (6page)
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The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore, the expression patterns of both protein and correlation with various clinical data in each tissue were analyzed. The expressions of both HERV-K Env and HERV-R Env protein were identified to be significantly high in most of the tumors compared with normal surrounding tissues. Correlations between HERV Env expressions and clinical investigations varied depending on the HERV types and cancers. Overall expression patterns of HERV-K Env and HERV-R Env proteins were different in every individual but a similar pattern of expressions was observed in the same individual. These results demonstrate the expression profiles of HERV-K and HERV-R Env proteins in various cancer tissues and provide a good reference for the association of endogenous retroviral Env proteins in the progression of various cancers. Furthermore, the results elucidate the relationship between HERV-Env expression and the clinical significance of certain cancers.
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참고문헌 (26)
참고문헌 신청
Li M / 2017 / Downregulation of Human endogenous retrovirus type K(HERV-K)viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth / Clin Cancer Res 23:5892~5911
Wang-Johanning F / 2012 / Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors / J Natl Cancer Inst 104:189~210
Kewitz S / 2013 / Expression and regulation of the endogenous retrovirus 3 in Hodgkin’s lymphoma cells / Front Oncol 3:179
Lee SH / 2014 / Elevation of human ERV3-1 env protein expression in colorectal cancer / J Clin Pathol 67:840~844
Rhyu DW / 2014 / Expression of human endogenous retrovirus env genes in the blood of breast cancer patients / Int J Mol Sci 15:9173~9183
Wang-Johanning F / 2012 / Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors / J Natl Cancer Inst 104:189~210
Kewitz S / 2013 / Expression and regulation of the endogenous retrovirus 3 in Hodgkin’s lymphoma cells / Front Oncol 3:179
Lee SH / 2014 / Elevation of human ERV3-1 env protein expression in colorectal cancer / J Clin Pathol 67:840~844
Rhyu DW / 2014 / Expression of human endogenous retrovirus env genes in the blood of breast cancer patients / Int J Mol Sci 15:9173~9183
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