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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 329 - 334 (6page)
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초록· 키워드
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Collagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effective domain (CED) which promotes collagen type I synthesis. Recombinant hCOL1A1-CED effectively induces cell proliferation and collagen biosynthesis in HDFs, as well as increased cell migration and elastin production. Based on these results, hCOL1A1-CED may be explored further for its potential use as a preventative agent against skin aging.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
El-Domyati M / 2002 / Intrinsic aging vs. photoaging : a comparative histopathological, immunohistochemical, and ultrastructural study of skin / Exp Dermatol 11:398~405
Mancini M / 2014 / MicroRNAs in human skin ageing / Ageing Res Rev 17:9~15
Ganceviciene R / 2012 / Skin anti-aging strategies / Dermatoendocrinol 4:308~319
Rendon MI / 2005 / Review of skin-lightening agents / Dermatol Surg 31:886~889
Petit L / 2003 / Skin-lightening products revisited / Int J Cosmet Sci 25:169~181
Mancini M / 2014 / MicroRNAs in human skin ageing / Ageing Res Rev 17:9~15
Ganceviciene R / 2012 / Skin anti-aging strategies / Dermatoendocrinol 4:308~319
Rendon MI / 2005 / Review of skin-lightening agents / Dermatol Surg 31:886~889
Petit L / 2003 / Skin-lightening products revisited / Int J Cosmet Sci 25:169~181
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