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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 305 - 310 (6page)
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Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and calcium overload in mitochondria, leading to disruption of mitochondrial membrane potential. Notably, long-term CRBN depletion using PROteolysis TArgeting Chimera (PROTAC) induced irreversible mitochondrial dysfunction, resulting in cell death. Our collective findings indicate that CRBN is required for mitochondrial homeostasis in cells.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Friedman JR / 2014 / Mitochondrial form and function / Nature 505:335~343
Hüttemann M / 2007 / Regulation of mitochondrial oxidative phosphorylation through cell signaling / Biochim Biophys Acta 1773:1701~1720
Ji Woong Lim / 2020 / Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention / BMB Reports 53(1):47~55
Belhadj Slimen I / 2014 / Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review / Int J Hyperthermia 30:513~523
Shokolenko I / 2009 / Oxidative stress induces degradation of mitochondrial DNA / Nucleic Acids Res 37:2539~2548
Hüttemann M / 2007 / Regulation of mitochondrial oxidative phosphorylation through cell signaling / Biochim Biophys Acta 1773:1701~1720
Ji Woong Lim / 2020 / Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention / BMB Reports 53(1):47~55
Belhadj Slimen I / 2014 / Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review / Int J Hyperthermia 30:513~523
Shokolenko I / 2009 / Oxidative stress induces degradation of mitochondrial DNA / Nucleic Acids Res 37:2539~2548
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