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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 136 - 141 (6page)
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Thyroid eye disease (TED) is a complex autoimmune disease with a spectrum of signs. we previously reported that trisialoganglioside (GT)1b is significantly overexpressed in the orbital tissue of TED patients, and that exogenous GT1b strongly induced HA synthesis in orbital fibroblasts. However, the signaling pathway in GT1b-induced hyaluronic acid synthase (HAS) expression in orbital fibroblasts from TED patients have rarely been investigated. Here, we demonstrated that GT1b induced phosphorylation of Akt/mTOR in a dose-dependent manner in orbital fibroblasts from TED patients. Both co-treatment with a specific inhibitor for PI3K and siRNA knockdown of TLR2 attenuated GT1b-induced Akt phosphorylation. GT1b significantly induced HAS2 expression at both the transcriptional and translational level, which was suppressed by specific inhibitors of PI3K or Akt/mTOR, and by siRNA knockdown of TLR2. In conclusion, GT1b induced HAS2 in orbital fibroblasts from TED patients via activation of the PI3Krelated signaling pathway, dependent on TLR2.
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참고문헌 (38)
참고문헌 신청
Kazim M / 2002 / Insights into the pathogenesis of thyroid-associated orbitopathy : evolving rationale for therapy / Arch Ophthalmol 120:380~386
Garrity JA / 2006 / Pathogenesis of graves ophthalmopathy : implications for prediction, prevention, and treatment / Am J Ophthalmol 142:147~153
Naik VM / 2010 / Immunopathogenesis of thyroid eye disease : emerging paradigms / Surv Ophthalmol 55:215~226
Bahn RS / 2010 / Graves’ ophthalmopathy / N Engl J Med 362:726~738
Smith TJ / 1989 / Connective tissue, glycosaminoglycans, and diseases of the thyroid / Endocr Rev 10:366~391
Garrity JA / 2006 / Pathogenesis of graves ophthalmopathy : implications for prediction, prevention, and treatment / Am J Ophthalmol 142:147~153
Naik VM / 2010 / Immunopathogenesis of thyroid eye disease : emerging paradigms / Surv Ophthalmol 55:215~226
Bahn RS / 2010 / Graves’ ophthalmopathy / N Engl J Med 362:726~738
Smith TJ / 1989 / Connective tissue, glycosaminoglycans, and diseases of the thyroid / Endocr Rev 10:366~391
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