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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 588 - 593 (6page)
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The accumulation of triglycerides (TGs) in macrophages induces cell death, a risk factor in the pathogenesis of atherosclerosis. We had previously reported that TG-induced macrophage death is triggered by caspase-1 and -2, therefore we investigated the mechanism underlying this phenomenon. We found that potassium efflux is increased in TG-treated THP-1 macrophages and that the inhibition of potassium efflux blocks TG-induced cell death as well as caspase-1 and -2 activation. Furthermore, reducing ATP concentration (known to induce potassium efflux), restored cell viability and caspase-1 and -2 activity. The activation of pannexin-1 (a channel that releases ATP), was increased after TG treatment in THP-1 macrophages. Inhibition of pannexin-1 activity using its inhibitor, probenecid, recovered cell viability and blocked the activation of caspase-1 and -2 in TG-treated macrophages. These results suggest that TG-induced THP-1 macrophage cell death is induced via pannexin- 1 activation, which increases extracellular ATP, leading to an increase in potassium efflux.
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참고문헌 (25)
참고문헌 신청
Lozano R / 2012 / Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010 : a systematic analysis for the Global Burden of Disease Study 2010 / Lancet 380:2095~2128
Rafieian-Kopaei M / 2014 / Atherosclerosis : process, indicators, risk factors and new hopes / Int J Prev Med 5:927~946
Parthasarathy S / 2010 / Oxidized low-density lipoprotein / Methods Mol Biol 610:403~417
Thomsen M / 2014 / Low nonfasting triglycerides and reduced allcause mortality : a mendelian randomization study / Clin Chem 60:737~746
Bersot T / 2006 / Hypertriglyceridemia : management of atherogenic dyslipidemia / J Fam Pract 55:S1~S8
Rafieian-Kopaei M / 2014 / Atherosclerosis : process, indicators, risk factors and new hopes / Int J Prev Med 5:927~946
Parthasarathy S / 2010 / Oxidized low-density lipoprotein / Methods Mol Biol 610:403~417
Thomsen M / 2014 / Low nonfasting triglycerides and reduced allcause mortality : a mendelian randomization study / Clin Chem 60:737~746
Bersot T / 2006 / Hypertriglyceridemia : management of atherogenic dyslipidemia / J Fam Pract 55:S1~S8
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