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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 357 - 366 (10page)
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초록· 키워드
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Currently, most biological research relies on conventional experimental techniques that allow only static analyses at certain time points in vitro or ex vivo. However, if one could visualize cellular dynamics in living organisms, that would provide a unique opportunity to study key biological phenomena in vivo. Intravital microscopy (IVM) encompasses diverse optical systems for direct viewing of objects, including biological structures and individual cells in live animals. With the current development of devices and techniques, IVM addresses important questions in various fields of biological and biomedical sciences. In this mini-review, we provide a general introduction to IVM and examples of recent applications in the field of immunology, oncology, and vascular biology. We also introduce an advanced type of IVM, dubbed real-time IVM, equipped with video-rate resonant scanning. Since the realtime IVM can render cellular dynamics with high temporal resolution in vivo, it allows visualization and analysis of rapid biological processes.
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참고문헌 (86)
참고문헌 신청
Jung K / 2017 / Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy / J Clin Invest 127:3039~3051
Jung K / 2013 / Endoscopic timelapse imaging of immune cells in infarcted mouse hearts / Circ Res 112:891~899
Choi M / 2015 / In vivo fluorescence microscopy : lessons from observing cell behavior in their native environment / Physiology (Bethesda) 30:40~49
Jung K / 2017 / Targeting CXCR4-dependent immunosuppressive Ly6C(low)monocytes improves antiangiogenic therapy in colorectal cancer / Proc Natl Acad Sci U S A 114:10455~10460
Weigert R / 2010 / Intravital microscopy : a novel tool to study cell biology in living animals / Histochem Cell Biol 133:481~491
Jung K / 2013 / Endoscopic timelapse imaging of immune cells in infarcted mouse hearts / Circ Res 112:891~899
Choi M / 2015 / In vivo fluorescence microscopy : lessons from observing cell behavior in their native environment / Physiology (Bethesda) 30:40~49
Jung K / 2017 / Targeting CXCR4-dependent immunosuppressive Ly6C(low)monocytes improves antiangiogenic therapy in colorectal cancer / Proc Natl Acad Sci U S A 114:10455~10460
Weigert R / 2010 / Intravital microscopy : a novel tool to study cell biology in living animals / Histochem Cell Biol 133:481~491
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