The Relationship of Leptin (+19) AG, Leptin (2548) GA, and Leptin Receptor Gln223Arg Gene Polymorphisms with Obesity and Metabolic Syndrome in Obese Children and Adolescents

Serap Bilge; Resul Yılmaz; Erhan Karaslan; Samet Ozer; Omer Ate?; Emel Ensari; Osman Demir

추천

검색

자료유형: 학술저널

저자정보: Serap Bilge (Gaziosmanpa?a University Hospital) Resul Yılmaz (Gaziosmanpa?a University Hospital) Erhan Karaslan (Gaziosmanpa?a University Hospital) Samet Ozer (Gaziosmanpa?a University Hospital) Omer Ate? (Gaziosmanpa?a University Hospital) Emel Ensari (Gaziosmanpa?a University Hospital) Osman Demir (Gaziosmanpa?a University Hospital)

저널정보: 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제3호

발행연도: 2021.1

수록면: 306 - 315 (10page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Obesity is defined as the abnormal or excessive accumulation of fat over acceptable limits. Leptin is a metabolic hormone present in the circulation in amounts proportional to fat mass. Leptin reduces food intake and increases energy expenditure, thus regulating body weight and homeostasis. Various polymorphisms are present in the leptin gene and its receptor. These polymorphisms may be associated with obesity. This study aimed to show the association of leptin (+19) AG, leptin (2548) GA, and Gln223Arg leptin receptor polymorphisms with obesity and metabolic syndrome in Turkish children aged 6?17 years, and to conduct further investigations regarding the genetic etiology of obesity. Methods: A total of 174 patients diagnosed with obesity and 150 healthy children who were treated at Tokat Gaziosmanpa?a Medical School Hospital between September 2014 and March 2015 were included in this study. The ages of the children were between 6 and 17 years, and anthropometric and laboratory results were recorded. Genotyping of leptin (+19) AG, leptin (2548) GA, and leptin receptor Gln223Arg polymorphisms was performed by polymerase chain reaction. Results: An association between leptin receptor Gln223Arg gene polymorphism and obesity was detected. Conclusion: Further studies are needed to determine the role of genetic etiologies and to indicate the role of leptin signal transmission impairment in the pathogenesis of obesity. We hope that gene therapy can soon provide a solution for obesity.

#Leptin #Obesity #Metabolic syndrome #Polymorphism #Polymerase chain reaction

참고문헌 (35)

참고문헌 신청

Önal Z / 2014 / Obesity in childhood / Okmeydanı Tıp Derg 30(Suppl 1):39~44

Arslan M / 2009 / Metabolic syndrome guide / Türkiye Endokrinoloji ve Metabolizma Derneği

Resul Yılmaz / 2019 / Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents / Pediatric Gastroenterology, Hepatology & Nutrition 22(5):460~469

Gul A / 2017 / Role of the polymorphisms of uncoupling protein genes in childhood obesity and their association with obesity-related disturbances / Genet Test Mol Biomarkers 21:531~538

Küçükkurt İ. / 2015 / The effects of leptin on other hormones / Kocatepe. Vet J 8:75~83

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!