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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제3호
- 발행연도
- 2021.1
- 수록면
- 245 - 255 (11page)
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초록· 키워드
오류제보하기
Necrotizing enterocolitis (NEC) is a disease with high morbidity and mortality that occurs mainly in premature born infants. The pathophysiologic mechanisms indicate that gastrointestinal dysbiosis is a major risk factor. We searched for relevant articles published in PubMed and Google Scholar in the English language up to October 2020. Articles were extracted using subject headings and keywords of interest to the topic. Interesting references in included articles were also considered. Network meta-analysis suggests the preventive efficacy of Bifidobacterium and Lactobacillus spp., but even more for mixtures of Bifidobacterium, Streptococcus, and Bifidobacterium, and Streptococcus spp. However, studies comparing face-toface different strains are lacking. Moreover, differences in inclusion criteria, dosage strains, and primary outcomes in most trials are major obstacles to providing evidence-based conclusions. Although adverse effects have not been reported in clinical trials, case series of adverse outcomes, mainly septicemia, have been published. Consequently, systematic administration of probiotic bacteria to prevent NEC is still debated in literature. The riskbenefit ratio depends on the incidence of NEC in a neonatal intensive care unit, and evidence has shown that preventive measures excluding probiotic administration can result in a decrease in NEC.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Bellodas Sanchez J / 2019 / Necrotizing enterocolitis / Neurogastroenterol Motil 31:e13569
Battersby C / 2017 / Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study / Lancet Gastroenterol Hepatol 2:43~51
Boccia D / 2001 / Nosocomial necrotising enterocolitis outbreaks : epidemiology and control measures / Eur J Pediatr 160:385~391
Samuels N / 2017 / Risk factors for necrotizing enterocolitis in neonates : a systematic review of prognostic studies / BMC Pediatr 17:105
Kuppala VS / 2011 / Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants / J Pediatr 159:720~725
Battersby C / 2017 / Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study / Lancet Gastroenterol Hepatol 2:43~51
Boccia D / 2001 / Nosocomial necrotising enterocolitis outbreaks : epidemiology and control measures / Eur J Pediatr 160:385~391
Samuels N / 2017 / Risk factors for necrotizing enterocolitis in neonates : a systematic review of prognostic studies / BMC Pediatr 17:105
Kuppala VS / 2011 / Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants / J Pediatr 159:720~725
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