지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 307 - 311 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Necrotizing enterocolitis (NEC) is one of the most serious complications of prematurity. Many risk factors can contribute to the development of NEC. The epidermal growth factor (EGF) plays a major role in intestinal barrier function, increases intestinal enzyme activity, and improves nutrient transport. The aim of this study was to assess the role of epidermal growth factor in the development of NEC in preterm neonates. Methods: In this study, 130 preterm neonates were included and divided into 3 groups, as follows: group 1, 40 preterm neonates with NEC; group 2, 50 preterm neonates with sepsis; and group 3, 40 healthy preterm neonates as controls. The NEC group was then subdivided into medical and surgical NEC subgroups. The serum EGF level was measured using enzyme-linked immunosorbent assay. Results: Serum EGF levels (pg/dL) were significantly lower in the NEC group (median [interquartile range, IQR], 9.6 [2-14]) than in the sepsis (10.1 [8-14]) and control groups (11.2 [8-14], P<0.001), with no significant difference between the sepsis and control groups, and were positively correlated with gestational age (r=0.7, P<0.001). A binary logistic regression test revealed that low EGF levels and gestational ages could significantly predict the development of NEC. The receiver-operating characteristic curve for EGF showed an optimal cutoff value of 8 pg/mL, with 73.3% sensitivity, 98% specificity, and an area under the curve of 0.92. Conclusion: The patients with NEC in this study had significantly lower serum EGF levels (P<0.001), which indicated that EGF could be a reliable marker of NEC in preterm neonates.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Descending Aorta Blood Flow Characteristics before the Development of Necrotizing Enterocolitis in Preterm Neonates
Neonatal medicine
2018 .01
-
Usefulness of Abdominal Sonography in Accurate Diagnosis for Necrotizing Enterocolitis
Neonatal medicine
2015 .01
-
NEC (Necrotizing Enterocolitis)
대한외과학회 학술대회 초록집
2019 .05
-
NEC (Necrotizing Enterocolitis)
대한외과학회 학술대회 초록집
2022 .11
-
Suppressive role of vascular endothelial growth factor on intestinal apoptosis in induced necrotizing enterocolitis in rats
Annals of Surgical Treatment and Research
2023 .09
-
Presentation Time of Necrotizing Enterocolitis Diagnosed by Sonography according to Gestational Age
Neonatal medicine
2015 .01
-
Double Intussusceptions with Necrotizing Enterocolitis Diagnosed in a Premature Infant
Neonatal medicine
2015 .01
-
신생아 위천공: 미숙아와 만삭아의 차이 비교
Neonatal medicine
2015 .01
-
Probiotics in the Prevention and Treatment of Necrotizing Enterocolitis
Pediatric Gastroenterology, Hepatology & Nutrition
2021 .01
-
극소저체중출생아에서 신생아 괴사성 장염의 침범 범위에 따른 예후 및 예측 인자
Neonatal medicine
2015 .01
-
단일 신생아집중치료실에서 완전 모유 수유 적용 이후 괴사성 장염의 발생 빈도 감소
Neonatal medicine
2017 .08
-
Small Bowel Intussusception in a Preterm Infant
Perinatology
2021 .01
-
Neonates and Pediatric Patients
대한외과학회 학술대회 초록집
2018 .11
-
성문 후상부에 발생한 대세포 신경내분비암종의 치료 1예
대한이비인후-두경부외과학회지
2022 .03
-
Lactobacillus reuteri DSM 17938 Improves Feeding Intolerance in Preterm Infants
Pediatric Gastroenterology, Hepatology & Nutrition
2019 .01
-
Antenatal corticosteroids and outcomes of preterm small-for-gestational-age neonates in a single medical center
Obstetrics & Gynecology Science
2018 .01
-
Comparison of Neonates and Non-neonates in Enterostomyrelated Complication and Mortality : A Retrospective Study
대한외과학회 학술대회 초록집
2019 .10
-
피부투과 기능성 펩타이드를 이용한 경피투과성 상피세포성장인자의 개발
대한화장품학회지
2019 .01
-
신생아의 저산소성 허혈성 뇌병증과 혈중 비타민 D 농도의 연관성: 체계적 문헌고찰 및 메타분석
병원약사회지
2021 .11
-
Non-derivatizing Tandem Mass Spectrometry Assay for Expanded Newborn Screening and Cutoffs for Preterm Neonates
Annals of Laboratory Medicine
2023 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0