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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The intent of the present work was to develop a simple, sensitive, accurate, precise, rapid and economical UV- spectrophotometric and reverse phase high pressure liquid chromatographic method for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms. UV-Spectrophotometry was carried out by simultaneous equation method using 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile (50:50) v/v as a solvent. The linearity range was 2-14 ㎍ mL<SUP>−1</SUP> for Spironolactone and Furosemide with a correlation coefficient ＞ 0.99. The chromatographic separation was achieved on 250 ㎜ × 4.6 ㎜, hypersil BDS C18 column with particle size 5 ㎛, by using an isocratic mixture of 0.02 M potassium dihydrogen phosphate buffer pH 3.5: Acetonitrile: tert butyl methyl ether (49:50:1) v/v/v as a solvent at a flow rate of 1 mL min<SUP>−1</SUP> and UV detection was carried out at 254 ㎚. The retention time were observed to be 3.666 and 6.661 minutes for Furosemide and Spironolactone respectively. The two developed methods were validated according to the ICH guidelines for accuracy, precision, linearity, LOD, LOQ and were found to be within the limits. It can be concluded that these two methods could be successfully used for the simultaneous estimation of Spironolactone and Furosemide in bulk and combined tablet dosage forms.
목차
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Figure of Merits
6. Conclusions
References
참고문헌 (37)
참고문헌 신청
G Giebisch, Arzneimittelforschung, 35(1A), 336-342 (1985).
A. Qureshi and I. J. McGilveray, Drug Dev. Ind. Pharm., 24, 995-1005 (1998).
M. E. Bosch, A. J. R. Sánchez, F. S Rojas and C. B. Ojeda, Int. J. Pharm. Biol. Sci., 3, 168-181 (2013).
E. Dinç and Ö. Üstünda?, Farmaco, 58, 1151-1161 (2003).
G. Kher, V. Ram, M. Kher and H. Joshi, Res. J. Pharm. Biol. Chem. Sci., 4, 365-377 (2013).
A. Qureshi and I. J. McGilveray, Drug Dev. Ind. Pharm., 24, 995-1005 (1998).
M. E. Bosch, A. J. R. Sánchez, F. S Rojas and C. B. Ojeda, Int. J. Pharm. Biol. Sci., 3, 168-181 (2013).
E. Dinç and Ö. Üstünda?, Farmaco, 58, 1151-1161 (2003).
G. Kher, V. Ram, M. Kher and H. Joshi, Res. J. Pharm. Biol. Chem. Sci., 4, 365-377 (2013).
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