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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 739 - 746 (8page)
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초록· 키워드
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As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ahnah Song / 2012 / Selection and characterization of lactic acid bacteria with improved antimicrobial activity to poultry diarrhea inducing-pathogen by genome shuffling / 석사 / 서울
Allen HK / 2013 / Treatment, promotion, commotion: antibiotic alternatives in food-producing animals / Trends Microbiol 21 : 114 ~ 119
Anal AK / 2007 /
Calinescu C / 2005 / Carboxymethyl high amylose starch (CM-HAS) as excipient for Escherichia coli oral formulations / Eur. J. Pharm. Biopharm 60 : 53 ~ 60
Chan ES / 2005 / Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium / Process Biochem 40 : 3346 ~ 3351
Allen HK / 2013 / Treatment, promotion, commotion: antibiotic alternatives in food-producing animals / Trends Microbiol 21 : 114 ~ 119
Anal AK / 2007 /
Calinescu C / 2005 / Carboxymethyl high amylose starch (CM-HAS) as excipient for Escherichia coli oral formulations / Eur. J. Pharm. Biopharm 60 : 53 ~ 60
Chan ES / 2005 / Bioencapsulation by compression coating of probiotic bacteria for their protection in an acidic medium / Process Biochem 40 : 3346 ~ 3351
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