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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 216 - 216 (1page)
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Alisma Rhizomes is used as a diuretic, hypolipidemic, anti-diabetic and anti-inflammatory agent in traditional East-Asian medicine. In this study, we tested the effect of Alisma Rhizomes on the α3β4 nicotinic acetylcholine (nACh) receptor channel current in Xenopus oocytes. The acetylcholine-induced inward peak current (IACh) was measured with the two-electrode voltage-clamp technique. This experiment shows that the α3β4 nACh receptor cRNA injected into oocytes followed by co-application with Alisma Rhizomes inhibited IACh in a noncompetitive or voltage insensitive condition. The half maximal inhibitory concentration (IC50) of Alisma Rhizomes was 12.5 ± 3.4 ug/ml and the Vmax was 55.4 ± 4 ... 전체 초록 보기
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