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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.2
- 발행연도
- 2021.6
- 수록면
- 157 - 165 (9page)
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초록· 키워드
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Mentha cordifolia (MC) is a popular herb used to flavor food in Thailand that exhibits several biological effects. The present study aimed to determine the role of MC in regulating glucose and lipid metabolism in mice fed a high-fat diet (HFD). ICR obese mice were fed an HFD (45 kcal% lard fat) for 12 weeks, with MC (100 and 200 mg/kg/d) treatment from Week 7. After treatment with MC for 6 weeks, mice showed significantly lower rates of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hyperlipidemia, and increased amounts of serum adiponectin. Furthermore, in mice treated with MC, serum interleukin-6 and tumor necrosis factor alpha were significantly inhibited and liver histology results showed decreased lipid accumulation and liver triglyceride content vs. untreated mice. In addition, MC treatment was associated with smaller fat cells and lower gene expression of liver sterol regulatory element binding protein 1c, acetyl-CoA carboxylase, and fatty acid synthase. However, MC treatment was associated with higher carnitine palmitoyltransferase 1a gene expression and significantly higher rates of adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in liver, but lower levels of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. These results indicate MC regulates glucose and lipid metabolism in a HFD-induced obese mouse model, possibly via activation of AMPK signaling pathway.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (44)
참고문헌 신청
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Cheng Y / 2014 / Decomposition of five phenolic compounds in high temperature water / J Braz Chem Soc 25:2102~2107
Divella R / 2019 / Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer / Int J Biol Sci 15:610~616
Acharaporn Duangjai / 2016 / Spirogyra neglecta inhibits the absorption and synthesis of cholesterol in vitro / Integrative Medicine Research 5(4):301~308
Egawa T / 2011 / Caffeine activates preferentially α1-isoform of 5’AMP-activated protein kinase in rat skeletal muscle / Acta Physiol 201:227~238
Cheng Y / 2014 / Decomposition of five phenolic compounds in high temperature water / J Braz Chem Soc 25:2102~2107
Divella R / 2019 / Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer / Int J Biol Sci 15:610~616
Acharaporn Duangjai / 2016 / Spirogyra neglecta inhibits the absorption and synthesis of cholesterol in vitro / Integrative Medicine Research 5(4):301~308
Egawa T / 2011 / Caffeine activates preferentially α1-isoform of 5’AMP-activated protein kinase in rat skeletal muscle / Acta Physiol 201:227~238
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UCI(KEPA) : I410-ECN-0101-2021-594-001866174