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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 12 - 26 (15page)
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초록· 키워드
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Background: Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) has been linked to allergic disease onset. Variations in the glutathione S-transferase (GST) gene family can impact the progression of allergic diseases. We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children"s Environmental Health (MOCEH) study.
Methods: The study sample comprised 349 infants and their mothers from the MOCEH study, for whom 1-hydroxypyrene (1-OHP) and 2-naphthol were measured in both the early period of pregnancy and late period of pregnancy. An infant was deemed to be affected by an allergic disease if diagnosed with or if developed at least one of the allergic diseases. A logistic regression analysis was performed to study the association between urinary 1-OHP and 2-naphthol levels during pregnancy and allergic diseases in 6-month-old infants. Furthermore, analyses stratified by maternal GSTM1 or GSTT1 present/null polymorphisms were performed.
Results: The risk of allergic diseases in 6-month-old infants was significantly increased in accordance with an increase in urinary 1-OHP during the early period of pregnancy (odds ratio [OR]: 1.84; 95% confidence interval [CI]: 1.05, 3.23; by one log-transformed unit of 1-OHP μg/g creatinine). The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP μg/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.
Conclusions: The present study found that infantile allergic diseases could be affected by intrauterine PAH exposure, particularly in the early prenatal period and the risk was limited to the maternal GSTT1 null type.
Methods: The study sample comprised 349 infants and their mothers from the MOCEH study, for whom 1-hydroxypyrene (1-OHP) and 2-naphthol were measured in both the early period of pregnancy and late period of pregnancy. An infant was deemed to be affected by an allergic disease if diagnosed with or if developed at least one of the allergic diseases. A logistic regression analysis was performed to study the association between urinary 1-OHP and 2-naphthol levels during pregnancy and allergic diseases in 6-month-old infants. Furthermore, analyses stratified by maternal GSTM1 or GSTT1 present/null polymorphisms were performed.
Results: The risk of allergic diseases in 6-month-old infants was significantly increased in accordance with an increase in urinary 1-OHP during the early period of pregnancy (odds ratio [OR]: 1.84; 95% confidence interval [CI]: 1.05, 3.23; by one log-transformed unit of 1-OHP μg/g creatinine). The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP μg/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.
Conclusions: The present study found that infantile allergic diseases could be affected by intrauterine PAH exposure, particularly in the early prenatal period and the risk was limited to the maternal GSTT1 null type.
목차
ABSTRACT
BACKGROUND
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (54)
참고문헌 신청
Mota IA / 2016 / Environmental Mycology in Public Health / Academic Press :35~43
Silverberg JI / 2013 / Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization / Pediatr Allergy Immunol 24(5):476~486
Adnan C / 2017 / Middleton's Allergy Essentials / Elsevier :57~60
Kim BK / 2016 / Allergies are still on the rise? A 6-year nationwide population-based study in Korea / Allergol Int 65(2):186~191
이은 / 2018 / 한국 소아 알레르기 역학연구의 과거와 미래 / Allergy Asthma & Respiratory Diseases :9~20
Silverberg JI / 2013 / Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization / Pediatr Allergy Immunol 24(5):476~486
Adnan C / 2017 / Middleton's Allergy Essentials / Elsevier :57~60
Kim BK / 2016 / Allergies are still on the rise? A 6-year nationwide population-based study in Korea / Allergol Int 65(2):186~191
이은 / 2018 / 한국 소아 알레르기 역학연구의 과거와 미래 / Allergy Asthma & Respiratory Diseases :9~20
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UCI(KEPA) : I410-ECN-0101-2021-517-001757657