지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 326 - 333 (8page)
- DOI
- 10.15188/kjopp.2020.12.34.6.326
이용수
초록· 키워드
오류제보하기
Nitrate–nitrite–nitric oxide (NO) pathway is a major alternative source of NO and is essential for NO - dependent physiological functions in body. Food supplements having nitrate/nitrite can improve metabolic syndromes including hypertension through antioxidant activity or vasodilation. The purpose of this study was to observe the effects of fermented garlic (F. garlic) having high concentration of NO₂ <SUP>-</SUP> on changes in blood flow and nitric oxide synthesis in the cerebral cortex of rodents. The generation of nitric oxide detected by a chemi-luminescence detector was higher in F. Garlic compared with NaNO₂ solution under artificial gastric juice with pH 2.0. Ether F. garlic or NaNO₂ diluted with artificial cerebrospinal fluid was directly applied into around the needle probe of laser Doppler flow meter that was located on epidural surface of the cortex. Direct application of F. garlic resulted in increase of cerebral blood flow detected by a laser Doppler flow meter with a dose-dependent manner. Compared with NaNO₂ solution, F. garlic produced changes in cerebral blood flow at lower concentration of NO₂<SUP>-</SUP>. Pretreatment of methylene blue, a guanylyl cyclase inhibitor prevented upregulation of cerebral blood flow by the treatment of F. garlic. In addition, the application of F. garlic with 250, 500ppm of NO₂<SUP>-</SUP> caused significantly the production of NO in the cortical tissue but NaNO₂ solution with 500ppm of NO₂<SUP>-</SUP> did not. In summary, these results suggested that F. garlic with high content of NO₂<SUP>-</SUP> induce increase in cerebral blood flow through nitric oxide-dependent signal pathway.
목차
서론
재료 및 방법
결과
고찰
References
참고문헌 (33)
참고문헌 신청
Bryan NS / 2015 / Nitric oxide enhancement strategies / Future Sci OA 1:Fso48
Bryan NS / 2019 / Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics / Mol Pharmacol 96:109~114
Lundberg JO / 2009 / Nitrate and nitrite in biology, nutrition and therapeutics / Nat Chem Biol 5:865~869
Bryan NS / 2005 / Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues / Nat Chem Biol 1:290~297
Blood AB / 2017 / The Medicinal Chemistry of Nitrite as a Source of Nitric Oxide Signaling / Curr Top Med Chem 17:1758~1768
Bryan NS / 2019 / Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics / Mol Pharmacol 96:109~114
Lundberg JO / 2009 / Nitrate and nitrite in biology, nutrition and therapeutics / Nat Chem Biol 5:865~869
Bryan NS / 2005 / Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues / Nat Chem Biol 1:290~297
Blood AB / 2017 / The Medicinal Chemistry of Nitrite as a Source of Nitric Oxide Signaling / Curr Top Med Chem 17:1758~1768
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
머리회전과 측정자세에 따른 뒤대뇌동맥의 혈류속도 변화
대한물리의학회지
2015 .01
-
A Study on the Relationship between Changes in Cerebral Blood Flow and Depression Index after Smoking
대한의생명과학회지
2023 .03
-
Immunomodulatory role of fermented garlic extract on macrophage cell proliferation, cytokine secretion and natural killer cell cytotoxicity
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Genetics of Cerebral Small Vessel Disease
대한뇌졸중학회지
2015 .01
-
Identification of regulated proteins by EGCG in cerebral cortex of middle cerebral artery occlusion animal model
한국실험동물학회 학술발표대회 논문집
2019 .01
-
The Impact of Hemodialysis and Arteriovenous Access Flow on Extracranial Hemodynamic Changes in End-Stage Renal Disease Patients
Journal of Korean Medical Science
2016 .01
-
불안정한 혈액공급위기를 대비하기 위한 환자혈액관리의 필요성
대한수혈학회지
2021 .12
-
국가혈액사업 전문성 및 역량 강화를 위한 제언
대한수혈학회지
2020 .01
-
뇌부종과 두개내압 조절을 위한 뇌관류압 최적화 치료
대한의사협회지
2023 .05
-
혈액제제 GMP, 무엇을 알고 어떻게 준비해야 하는가?
대한수혈학회지
2020 .01
-
Suppression of nitric oxide (NO) production by traditional medicine
셀메드
2018 .05
-
Diffuse cerebral microbleeds in a young adult with Down syndrome
Annals of Clinical Neurophysiology
2021 .01
-
국내 혈액사업 근황(2015∼2022)
대한수혈학회지
2024 .08
-
코로나19 유행 기간 헌혈 인식과 대한적십자사 대응에 관한 설문조사
대한수혈학회지
2021 .12
-
Revascularization of Concurrent Renal and Cerebral Artery Stenosis in a 14-Year-Old Girl with Takayasu Arteritis and Moyamoya Syndrome
Journal of Korean Medical Science
2018 .01
-
Patient Blood Management
대한외과학회 학술대회 초록집
2021 .11
-
Intra-operative cerebral blood flow assessment by indocyanine green video-angiography after temporary arterial occlusion in aneurysm surgery and its clinical implications: a prospective study
Journal of Cerebrovascular and Endovascular Neurosurgery
2021 .09
-
A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
오메가 3 지방산이 뇌혈류 및 혈관저항에 미치는 영향: 예비연구
Annals of Clinical Neurophysiology
2015 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
비타민 E 흡수에 미치는 인삼 Saponin분획의 영향 (The effect of ginseng saponin fraction on the absorption of vitamin E )
주충노
,
김재원
Journal of Ginseng Research
1984
.12
Aspergillus fumigatus 발효 추출물의 멜라닌 합성 억제 효과
송태양
,
김창원
,
강미옥
외 2명
생약학회지(Korean Journal of Pharmacognosy)
2021
.06
추출방법을 달리한 달맞이꽃 추출물의 항산화 및 항균 활성
김진학
,
이신호
Food Science and Preservation
2016
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-519-001408920