A New Tool to Predict Survival after Radiosurgery Alone for Newly Diagnosed Cerebral Metastases

Rades, Dirk; Huttenlocher, Stefan; Dziggel, Liesa; Blanck, Oliver; Hornung, Dagmar; Mai, Khoa Trong; Ngo, Trang Thuy; Pham, Thai Van; Schild, Steven

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자료유형: 학술저널

저자정보: Rades, Dirk (Department of Radiation Oncology, Faculty of Medicine, University of Lubeck) Huttenlocher, Stefan (Department of Radiation Oncology, Faculty of Medicine, University of Lubeck) Dziggel, Liesa (Department of Radiation Oncology, Faculty of Medicine, University of Lubeck) Blanck, Oliver (Department of Radiosurgery, CyberKnife Centre Northern Germany) Hornung, Dagmar (Department of Radiation Oncology, Faculty of Medicine, University of Hamburg) Mai, Khoa Trong (Department of Nuclear Medicine, Faculty of Medicine Hanoi Medical University) Ngo, Trang Thuy (Department of Radiation Oncology, Nuclear Medicine and Oncology Center, Bach Mai Hospital) Pham, Thai Van (Department of Radiation Oncology, Nuclear Medicine and Oncology Center, Bach Mai Hospital) Schild, Steven (Department of Radiation Oncology, Mayo Clinic Scottsdale)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제7호

발행연도: 2015.1

수록면: 2,967 - 2,970 (4page)

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Many patients with few cerebral metastases receive radiosurgery alone. The goal of this study was to create a tool to estimate the survival of such patients. To identify characteristics associated with survival, nine variables including radiosurgery dose, age, gender, Eastern cooperative oncology group performance score (ECOG-PS), primary tumor type, number/size of cerebral metastases, location of cerebral metastases, extra-cerebral metastases and time between cancer diagnosis and radiosurgery were analyzed in 214 patients. On multivariate analysis, age (p=0.03), ECOG-PS (p=0.02) and extra-cerebral metastases (p<0.01) had significant impacts on survival. Scoring points for each patient were obtained from 12-month survival rates (in %) related to the significant variables divided by 10. Addition of the scoring points of the three variables resulted in a patient's total predictive score. Two groups were designed, A (10-14 points) and B (16-17 points). Twelve-month survival rates were 33% and 77%, respectively (p<0.001). Median survival times were 8 and 20 months, respectively. Because most patients of group A died from extra-cerebral disease and/or new cerebral lesions, early systemic treatment and additional WBI should be considered. As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group.

#Cerebral metastases #radiosurgery alone #survival #prognostic factors #predictive tool

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