지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 558 - 564 (7page)
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초록· 키워드
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Objective: To investigate the prognostic significance of preoperative lymphocyte-monocyte ratio (LMR) in elderly patients with advanced epithelial ovarian cancer (EOC) receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy.
Methods: A total of 42 elderly patients (≥65 years) diagnosed with EOC who are receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2009 to 2012 was included. LMR was calculated from complete blood cell count sampled before operation. Receiver operating characteristic (ROC) curves were used to calculate optimal cut-off values for LMR. Prognostic significance with respect to overall survival (OS) and progression-free survival (PFS) were determined using log-rank test and Cox regression analysis.
Results: The optimized LMR cut-off value determined by ROC curve analysis was 3.63 for PFS and OS. The high LMR group (LMR ≥3.63) was found to be significantly more associated with optimal debulking (P=0.045) and platinum response (P=0.018) than the low LMR group. In addition, Kaplan-Meier analysis revealed the LMR-high group was significantly more associated with high PFS and OS rates (P=0.023 and P=0.033, respectively), and univariate analysis revealed that a high LMR, histology type, and optimal debulking and platinum responses were significantly associated with prolonged PFS and OS. However, subsequent Cox multivariate analysis showed only optimal debulking and platinum response were independent prognostic factors of PFS or OS.
Conclusion: This study suggests that LMR might be associated with treatment and survival outcomes in elderly patients with EOC receiving standard oncology treatment.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alphs HH / 2006 / Predictors of surgical outcome and survival among elderly women diagnosed with ovarian and primary peritoneal cancer / Gynecol Oncol 103 : 1048 ~ 1053
Asher V / 2011 / Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer / Clin Transl Oncol 13 : 499 ~ 503
Chan JK / 2006 / Ovarian cancer in younger vs older women: a population-based analysis / Br J Cancer 95 : 1314 ~ 1320
Chen L / 2015 / Decreased pretreatment lymphocyte/monocyte ratio is associated with poor prognosis in stage Ib1-IIa cervical cancer patients who undergo radical surgery / On
Cloven NG / 1999 / Management of ovarian cancer in patients older than 80 years of age / Gynecol Oncol 73 : 137 ~ 139
Asher V / 2011 / Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer / Clin Transl Oncol 13 : 499 ~ 503
Chan JK / 2006 / Ovarian cancer in younger vs older women: a population-based analysis / Br J Cancer 95 : 1314 ~ 1320
Chen L / 2015 / Decreased pretreatment lymphocyte/monocyte ratio is associated with poor prognosis in stage Ib1-IIa cervical cancer patients who undergo radical surgery / On
Cloven NG / 1999 / Management of ovarian cancer in patients older than 80 years of age / Gynecol Oncol 73 : 137 ~ 139
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