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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.4
- 발행연도
- 2020.12
- 수록면
- 389 - 399 (11page)
- DOI
- 10.3746/pnf.2020.25.4.389
이용수
초록· 키워드
오류제보하기
Silkworm pupae (Bombyx mori) is an edible insect that has been reported to contain high-quality proteins, lipids, minerals, and vitamins, and to possess high antioxidant activity. However, there have been no studies on the neuroprotective effects of silkworm pupae. Therefore, we investigated a water extract of silkworm pupae with protease (WSP) as a functional and therapeutic candidate for neurodegenerative disorders. First, we evaluated the effect of WSP on oxidative stress-induced mouse hippocampal neuronal cells (HT-22 cells). Cell viability diminished by addition of glutamate but was significantly recovered by WSP treatment. Furthermore, WSP significantly decreased the release of lactate dehydrogenase and generation of intracellular reactive oxygen species in oxidative stress-induced cells. In addition, in scopolamine-treated mice, WSP attenuated memory impairment, as demonstrated in the Morris water maze and passive avoidance tests, indicating protection of neuronal cells against oxidative damage. Moreover, WSP prevented scopolamine-induced increases in acetylcholinesterase activity and decreases in choline-acetyltransferase activity. Finally, treatment with WSP enhanced the antioxidant defense system by regulating the activities of antioxidant enzymes. Overall, this study showed that WSP exerted antioxidant and memory enhancing action against oxidative stress.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (48)
참고문헌 신청
Akhtar Y / 2018 / Proteins in Food Processing / Woodhead Publishing :263~288
Altomare AA / 2020 / Silkworm pupae as source of high-value edible proteins and of bioactive peptides / Food Sci Nutr 8:2652~2661
AOAC / 1990 / Official methods of analysis / Association of Official Analytical Chemists :8~35
Baek SY / 2020 / Neuroprotective effect of carotenoid-rich Enteromorpha prolifera extract via TrkB/Akt pathway against oxidative stress in hippocampal neuronal cells / Mar Drugs 18:372
Baek SY / 2020 / Enteromorpha prolifera extract improves memory in scopolamine-treated mice via downregulating amyloid-β expression and upregulating BDNF/TrkB pathway / Antioxidants 9:620
Altomare AA / 2020 / Silkworm pupae as source of high-value edible proteins and of bioactive peptides / Food Sci Nutr 8:2652~2661
AOAC / 1990 / Official methods of analysis / Association of Official Analytical Chemists :8~35
Baek SY / 2020 / Neuroprotective effect of carotenoid-rich Enteromorpha prolifera extract via TrkB/Akt pathway against oxidative stress in hippocampal neuronal cells / Mar Drugs 18:372
Baek SY / 2020 / Enteromorpha prolifera extract improves memory in scopolamine-treated mice via downregulating amyloid-β expression and upregulating BDNF/TrkB pathway / Antioxidants 9:620
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