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자료유형
학술저널
저자정보
Yang, Jae-Wook (School of Pharmacy, Western University) Lee, Do-Kyung (Department of Pharmacy, Sahmyook University) Kim, Yuna (Department of Pharmacy, Sahmyook University) Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) Kim, Kyung-Jae (Department of Pharmacy, Sahmyook University) Ha, Nam-Joo (Department of Pharmacy, Sahmyook University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제3호
발행연도
2007.1
수록면
329 - 336 (8page)

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Enterococcus faecalis and Enterococcus faecium isolated from Korea patients in 1998 and 2005 were tested for susceptibility to nine different antimicrobial agents, including vancomycin and teicoplanin. Polymerase chain reaction (PCR) was used for the detection of several van-comycin resistance genes such as vanA('high level'), varB ('moderate high level'), vanC1 and vanC2 ('low level'). Both E. faecalis and E. faecalis exhibited a resistance of 80% and more than 60% to synercid and mupirocin, respectively. Moreover, an average of 76% of all isolates was resistant to ciprofloxacin, gentamicin, lincomycin, cefotaxime, and meropenem, confirm-ing the multiple drug resistance of most of the isolates. No resistance to vancomycin or teicoplanin was observed in the 998 E. faecalis and E. faecium isolates. However, the 2005 E. faecalis and E. faecium isolates exhibited resistance of 16% and 12% to vancomycin and teicoplanin, respectively. In addition, vanA gene was detected in 4 strains of 2005 E. faecium lisolates, thus showing a high resistance to vancomycin. No other vancomycin resistancegenes, including vanB, vanC1, and varC2, were found in our isolates. In this study, we com-pared the occurrence of antimicrobial resistance and the presence of specific resistance genes in E. faecalis and E. faecalis. The results showed that the 2005 isolates were usually more resistant than the 1998 isolates.

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