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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제5호
- 발행연도
- 2007.1
- 수록면
- 570 - 580 (11page)
이용수
초록· 키워드
오류제보하기
A series of D-erythro ceramide analogues, N-(2S,3R,4E)-1 ,3-dihydroxy-5-phenyl pent4-en-2-yl alkyl sulfonamides, were synthesized and evaluated for their in vitro cytotoxic activities against five human tumor ceil lines. The aromatic sullen amido ceramide analogue (10f)showed more potent cytotoxic activity than that of the B13, indicating that a sulfonamide group appears to serve as a bioisostere of an amide in drug design. Variations in the alkyl sulfonyl chain length signifcantly influenced the cytotoxic activity of the sulfonamido ceramide analogues, but the introduction of a para halogen on the phenyl ring of aromatic ceramide analogues had no affect on the activity.
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