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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제11호
- 발행연도
- 2007.1
- 수록면
- 1,387 - 1,391 (5page)
이용수
초록· 키워드
오류제보하기
Two new triterpene glycosides, namely holothurin $A_3$ (1) and $A_4$ (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 20 NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations $(IC_{50})$ of 0.87 and $0.32{\mu}g/mL$ (for compound 1) and of 1.12 and $0.57{\mu}g/mL$ (for compound 2), respectively.
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