지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제27권 제1호
- 발행연도
- 2004.1
- 수록면
- 94 - 98 (5page)
이용수
초록· 키워드
오류제보하기
Effects of dopaminergic drugs on the degranulation of mast cells (RBL-2H3 cells) and the nitric oxide production from macrophage cells (RAW 264.7) were studied. Among the dopaminergic agonists and antagonists tested, bromocriptine, 7-OH-DPAT, haloperidol, and clozapine showed potent inhibitions of mast cell degranualtion ($IC_{50} value, 5 \mu$ M). However, these dopaminergic agents did not affect the tyrosine phosphorylations of the signaling components of the high affinity IgE receptor ($Fc\varepsilonRI$), such as Syk, $PLC\gamma1$, and $PLC\gamma2$.; This suggested that these signaling components were not involved in the inhibition of the mast cell degranulation by these compounds. On the other hand, dopamine, bromocriptine, 7-OH-DAPT, and haloperidol markedly inhibited the nitric oxide production from RAW 264.7 cells ($IC_{50}$ values, 10-20$\mu$M). Bromocriptine, a dopamine agonist that is routinely used for the treatment of Parkinsons disease, inhibited the expression of the inducible nitric oxide synthase at an early stage of the LPS-induced protein expression in a dose-dependent manner. The results suggested that these dopaminergic agents, when used for the treatment of dopamine receptors-related diseases, such as Schizophrenia or Parkinsons disease, might have additional beneficial effects.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of dopamine agonists and antagonists on the degranulation of mast cells and LPS-induced nitric oxide production in macrophage cells
대한약학회 학술대회
2001 .01
-
Excavation of Lead Compounds that Inhibit Mast Cell Degranulation by Combinatorial Chemistry and Activity-Guided
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
DMSO inhibits the degranulation of mast cells by a affecting the signaling components of Fc$\varepsilon$RI
대한약학회 학술대회
2000 .01
-
Effect of p70 S6 kinase inhibitor on production of nitric oxide in RAW 264.7 cells
대한약학회 학술대회
2000 .01
-
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective
International Neurourology Journal
2015 .01
-
Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of $M_2$-type pyruvate kinase
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
-
Mast Cells in Allergic Asthma and Beyond
Yonsei Medical Journal
2010 .01
-
알레르기 염증에서의 비만세포 역할과 비만세포 관련 질환
Allergy Asthma & Respiratory Diseases
2017 .01
-
이상운동질환에서의 도파민 신경계 영상
핵의학분자영상
2007 .01
-
가미옥병풍산(加味玉屛風散)의 비만세포에서의 알레르기 반응에 대한 효과 연구
대한본초학회지(본초분과학회지)
2011 .01
-
삼묘환(三妙丸)의 LPS에 의해 활성화된 RAW 264.7 cells과 BV-2 Microglia cells로부터 생성되는 nitric oxide 및 $TNF-{\alpha}$의 생성억제효과
대한본초학회지(본초분과학회지)
2006 .01
-
Resverotrol inhibits the degranulation of mast cell by interfering the IgE receptor-mediated regulation of pyruvate kinases in RBL-2H3 cells
대한약학회 학술대회
2001 .01
-
Inhibition of Nitric Oxide Production from lipopolysaccharide-Treated RAW 264.7 Cells by Synthetic Flavones：Structure-Activity Relationship and Action Mechanism
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
The Significance of the Mast Cell in Rheumatic Disease
한국응용약물학회 추계학술발표논문집
2001 .01
-
Efficient Induction of Dopaminergic Neurons from Embryonic Stem Cells for Application to Parkinson's Disease
Yonsei Medical Journal
2004 .01
-
꾸지뽕나무 추출물의 비만세포 억제에 의한 항알레르기 효과 및 기전
약학회지
2012 .01
-
노화가 사람 치은섬유아세포의 nitric oxide와 inducible nitric oxide synthase 발현에 끼치는 영향
Journal of Periodontal & Implant Science
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0