지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Mast cells play an important role in early and late phase allergic reactions through allergen and IgE-dependent release of histamine, proteases, prostaglandins, and several multifunctional cytokines. In this study, we investigated whether Cudrania tricuspidata extract (CTE) suppresses IgE-mediated allergic responses in mast cells, an allergic animal model, and its mechanism of action in mast cells. We found that CTE inhibited IgE-mediated degranulation and cytokine production in rat basophilic leukemia (RBL)-2H3 mast cells and bone marrow-derived mast cells (BMMC), as well as passive cutaneous anaphylaxis (PCA) in mice. With regard to its mechanism of action, CTE suppressed the activating phosphorylation of spleen tyrosine kinase (Syk), a key enzyme in mast cell signaling processes and that of LAT, a downstream adaptor molecule of Syk in $Fc{\varepsilon}RI$-mediated signal pathways. CTE also suppressed the activating phosphorylation of mitogen-activated protein (MAP) kinases and Akt. The present results strongly suggest that the anti-allergic activity of CTE is mediated through inhibiting degranulation and allergic cytokine secretion by inhibition of Syk kinase in mast cells. Therefore, CTE may be useful for the treatment of allergic diseases.
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참고문헌 (15)
참고문헌 신청
Holgate, S. T. / 2008 / Treatment strategies for allergy and asthma / Nat. Rev. Immunol 8:218
Beaven, M. A. / 2009 / perception of the mast cell from Paul Ehrlich to now / Eur. J. Immunol 39:11
Galli, S. J. / 1993 / New concepts about the mast cells / New Eng. J. Med 328:257
Paolini, R. / 1991 / Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engantigenement and disengantigenement / Nature 353:855
Gilfillan, A. M. / 2006 / Integrated signalling pathways for mast-cellactivation / Nat. Rev. Immunol 6:218
Beaven, M. A. / 2009 / perception of the mast cell from Paul Ehrlich to now / Eur. J. Immunol 39:11
Galli, S. J. / 1993 / New concepts about the mast cells / New Eng. J. Med 328:257
Paolini, R. / 1991 / Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engantigenement and disengantigenement / Nature 353:855
Gilfillan, A. M. / 2006 / Integrated signalling pathways for mast-cellactivation / Nat. Rev. Immunol 6:218
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