지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제37권 제9호
- 발행연도
- 2014.1
- 수록면
- 1,177 - 1,182 (6page)
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초록· 키워드
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It was reported that mast cell degranulation is inversely related to the enzymatic activity of $M_2$-type pyruvate kinase ($M_2PK$). This study shows that activation of high-affinity IgE receptor ($Fc{\varepsilon}RI$) evokes a sequential dual regulation of $M_2PK$, i.e., an immediate decrement followed by slow phase increment of enzymatic activities. Changes in the activities of $M_2PK$ and mast cell degranulation showed similar time course after antigenic stimulation of $Fc{\varepsilon}RI$. The immediate inhibition of $M_2PK$ involved tyrosine phosphorylation, and subsequently led to a cellular accumulation of glycolytic intermediates, including fructose 1,6-biphosphate (FBP), a feedforward activator of $M_2PK$. As the cellular levels of FBP were increased, both the enzymatic acitivity of $M_2PK$ and mast cell degranulation slowly returned to near basal levels. A-Raf, when exogenously introduced into RBL-2H3 cells, phosphorylated $M_2PK$ on the serine residues, elevated enzyme activities of $M_2PK$, and resulted in the inhibition of degranulation. These results suggest that dual regulation of $M_2PK$ which involves the phosphorylation of $M_2PK$ and accumulation of a feedforward activator of $M_2PK$ plays important roles in the control of mast cell degranulation.
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