지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 137 - 143 (7page)
이용수
초록· 키워드
오류제보하기
Objectives : Catalpa ovata G. Don (Bignoniaceae) has been shown to possess a variety of pharmacological activities. However, the effect of Catalpa ovata G. Don on endothelial adhesion molecule expression has not been reported. Methods : To examine the effect of Catalpa ovata G. Don on the expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs) stimulated with tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), we used various methods such as Western blot analysis, reverse tranascription-polymerase chain reaction (RT-PCR), and luciferase activity assay. Results : 1. The extract of Catalpa ovata G. Don inhibited the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in HUVECs stimulated with TNF-${\alpha}$. 2. The extract of Catalpa ovata G. Don reduced TNF-${\alpha}$-induced adhesion of leukocytes to HUVECs. 3. In addition, The extract of Catalpa ovata G. Don inhibited the promoter activities of ICAM-1 and VCAM-1. Conclusions : These results that Catalpa ovata G. Don may be beneficial in the treatment of inflammatory such as atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
1999 / Atherosclerosis is an inflammatory disease 138:S419~S420
2001 / Atherosclerosis the road head 104:503~516
1991 / Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis :788~251 791
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock yet succumb to L mo(cytogenes infection):457~67
jclininvest1973;52 / Culture of human endothelial cells derived from umbilical veins Identification by morphologic and immunologic criteria :2745~56
2001 / Atherosclerosis the road head 104:503~516
1991 / Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis :788~251 791
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock yet succumb to L mo(cytogenes infection):457~67
jclininvest1973;52 / Culture of human endothelial cells derived from umbilical veins Identification by morphologic and immunologic criteria :2745~56
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