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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 149 - 154 (6page)
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초록· 키워드
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Porphyromonas gingivalis, a major periodontal pathogen,
has been implicated in the initiation and progression of
periodontal disease. Endothelial dysfunction (Editor note:
Aberrant and dysfunction are somewhat redundant. The
authors may want to choose one or the other.) contributes to
chronic periodontal inflammation. Using cDNA-representational
difference analysis, we found that P.gingivalis
lipopolysaccharide differentially induces a number of genes
in human microvascular endothelial cells. Among these
upregulated genes, we focused on intercellular adhesion
molecule-1 (VCAM-1), which is crucial for leukocyte
recruitment during vascular inflammation. P. gingivalis
LPS significantly increased the expression of vascular cell
adhesion molecule-1 (VCAM-1) as well as ICAM-1.
Promoter assays revealed that the transcription of these cell
adhesion molecules was mainly regulated by nuclear factor-
κB (NF-κB) in endothelial cells. Furthermore, P. gingivalis
LPS significantly increased leukocyte adhesiveness to
microvascular endothelial cells and to aortic endothelium.
Taken together, our results demonstrate that P. gingivalis
LPS activates microvascular endothelial cells through NF-
κB-dependent expression of cell adhesion molecules.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Bainbridge BW / 2001 / Porphyromonas gingivalis lipopolysaccharide: An unusual pattern recognition receptor ligand for the innate host defense system / Acta Odontologica Scan
Coats SR / 2003 / Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells / Infect and
DeCarlo AA / 2008 / Isolation and characterization of human gingival microvascular endothelial cells / ?Journal of?Periodontal Research? 43 : 246 ~ 254
Harokopakis E / 2005 / Integrin activation by bacterial fimbriae through a pathway involving CD14, tolllike receptor 2, and phosphatidylinositol-3-kinase / European?Journal o
Kim SR / 2008 / Visfatin enhances ICAM-1 and VCAM-1 expression through ROSdependent NF-kappaB activation in endothelial cells / Biochimica et Biophysica Acta (BBA) - Molecula
Coats SR / 2003 / Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells / Infect and
DeCarlo AA / 2008 / Isolation and characterization of human gingival microvascular endothelial cells / ?Journal of?Periodontal Research? 43 : 246 ~ 254
Harokopakis E / 2005 / Integrin activation by bacterial fimbriae through a pathway involving CD14, tolllike receptor 2, and phosphatidylinositol-3-kinase / European?Journal o
Kim SR / 2008 / Visfatin enhances ICAM-1 and VCAM-1 expression through ROSdependent NF-kappaB activation in endothelial cells / Biochimica et Biophysica Acta (BBA) - Molecula
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