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학술저널
저자정보
하연귀 (대구한의대 한의학과 폐계내과학교실) 박미연 (대구한의대 한의학과 폐계내과학교실) 최해윤 (대구한의대 한의학과 폐계내과학교실) 김종대 (대구한의대 한의학과 폐계내과학교실) 송광규 (대구한의대 한의학과 폐계내과학교실)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제19권 제3호
발행연도
2005.1
수록면
753 - 759 (7page)

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In order to evaluate the in vivo synergic effect of Eunkyo-san with quinolone antibiotics, rufloxacin (RUFX), the viable bacterial numbers and histopathological changes were monitored after experimental respiratory infection with Klebsiella peumoniae NCTC 9632. The obtained results were as follows : In RUFX group, the viable bacterial numbers were significantly decreased compared to those of control group and these were more dramatically decreased compared to those of single treatment with RUFX, respectively in concomitant treated groups with Eunkyo-san. In control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to those of control group in RUFX group, and these were more dramatically decreased compared to those of single treatment with RUFX, respectively in concomitant treated groups with Eunkyo-san. In RUFX group, the LSA% (luminal surface of alveolar%) were significantly increased compared to those of control group and these were more dramatically decreased compared to those of single treatment with RUFX, respectively in concomitant treated groups with Eunkyo-san. According to these results, it is considered that in vivo antibacterial activity of RUFX group was dramatically increased by concomitant use of Eunkyo-san against K. pneumoniae NCTC 9632 infection of respiratory tract.

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