지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 521 - 532 (12page)
이용수
초록· 키워드
오류제보하기
Abjectives & Methods : In order to evaluate the in vitro synergic effects of Eunkyo-san which is a traditional poly-herbal formula that has been used in the treatment of respiratory diseases in oriental medicine, and quinolone antibiotics, rufloxacin (RUFX) and iprofloxacin (CPFX), experimentation was designed to determine minimal inhibitory concentration (MIC), MIC50 and MIC90 of single use of quinolones and concomitant treatment with Eunkyo-san against 5 strains of aerobic gram negative bacteria, Escherichia coli, Klebsiella peumoniae, Hemophilus influenzae, Citrobacter freundii and Pseudomonas aeruginosae.
Results : In the case of aerobic gram negative bacteria, the MIC, MIC50 and MIC90 against Klebsiella peumoniae and Citrobacter freundii significantly decreased in concomitant-treated groups with Eunkyo-san compared to those of single-treated groups of RUFX and CPFX, respectively. However, no significant changes were demonstrated against Echerichia coli, Hemophilus influenzae and Pseudomonas aeruginosae.
Conclusion : According to these results, concomitant use of Eunkyo-san against some strains of aerobic gram-negative bacteria dramatically increases in vitro antibacterial activity of RUFX and CPFX, and the increase and selectivity of antibacterial activities against these strains is attributable to Eunkyo-san, and not RUFX or CPFX activity.
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참고문헌 (25)
참고문헌 신청
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/ / Bonfiglio G. In vitro activity of a new quinolone : 260 ~ 9
/ / Fass RJ. Ciprofloxacin. Best use of this new broad-spectrum antibiotic. Postgrad Med. 1990 : 117 ~ 22
/ / Neri MG. In vitro short-term and long-term cytotoxicity of fluoroquinolones on murine cell lines. Indian J Exp Biol. 1994 : 113 ~ 8
/ / in vitro and in vivo antibacterial activity. Drugs Exp Clin Res. 1989 : 11 ~ 934 5
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