지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 229 - 235 (7page)
이용수
초록· 키워드
오류제보하기
Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells. In particular, Plk1 is highly expressed in cancer cells. Plk1 inhibitors, such as BI2536, have been widely used to prevent cell division as an anticancer drug. In this study, the fertilized murine oocytes were treated with BI2536 for 30 min after recovery from the oviduct to investigate the effect of down-regulation of Plk1 in the in vivo-fertilized murine embryos. Then, the localization and expression of Plk1 was observed by immunofluorescence staining. The sperm which had entered into the oocyte cytoplasm did not form male pronuclei in BI2536-treated oocytes. The BI2536-treated oocytes showed significantly lower expression of Plk1 than non-treated control group. In addition, alpha-tubulin and Plk1 gathered around sperm head in non-treated oocytes, while BI2536-treated oocytes did not show this phenomenon. The present study demonstrates that the Plk1 inhibitor, BI2536, hinders fertilization by inhibiting the formation of murine male pronucleus.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Adverse effect of IL-6 on the in vitro maturation of porcine oocytes
Korean Journal of Agricultural Science
2021 .09
-
Rapamycin treatment during prolonged in vitro maturation enhances the developmental competence of immature porcine oocytes
한국축산학회지
2024 .09
-
소 난자의 체외성숙시 난구세포와 난세포질에서 다르게 발현되는 Matrix Metalloproteinases의 분석
한국수정란이식학회지
2018 .01
-
Heat waves impair cytoplasmic maturation of oocytes and preimplantation development in Korean native cattle (Hanwoo)
Korean Journal of Agricultural Science
2018 .09
-
Fertilizing capacity of cryopreserved sperm of Chirostoma jordani (Woolman, 1894)
Fisheries and Aquatic Sciences
2024 .05
-
DNA damage repair is suppressed in porcine aged oocytes
한국축산학회지
2021 .09
-
Effects of lipopolysaccharides on the maturation of pig oocytes
Korean Journal of Agricultural Science
2021 .03
-
Antioxidant Effect of Alpha-Linolenic Acid during In Vitro Maturation in Porcine Oocytes
한국동물번식학회지
2017 .01
-
Endoplasmic Stress Inhibition during Oocyte Maturation Improves Preimplantation Development of Cloned Pig Embryos
한국수정란이식학회지
2017 .01
-
돼지 난자의 체외성숙과 배아발달 동안 ROS와 항산화제의 영향
한국동물번식학회지
2017 .01
-
Effect of Alpha Lipoic Acid on in vitro Maturation of Porcine Oocytes and Subsequent Embryonic Development after Parthenogenetic Activation
한국수정란이식학회지
2017 .01
-
소 난소 저온 보존이 난자의 체외 발달에 미치는 영향
한국수정란이식학회지
2016 .01
-
The Beneficial Effects of Ferulic Acid supplementation during In Vitro Maturation of Porcine Oocytes on Their Parthenogenetic Development
한국수정란이식학회지
2017 .01
-
Effect of Alpha Lipoic Acid as an Antioxidant Supplement during In Vitro Maturation Medium on Bovine Embryonic Development
한국수정란이식학회지
2017 .01
-
Influence of Autophagy Induction after Hormone Treatment on Oocytes Maturation of Porcine
한국수정란이식학회지
2018 .01
-
Role of Golgi Apparatus on Regulation of Sec61β, COPG2 and Epidermal Growth Factor during Oocyte Maturation
한국동물번식학회지
2015 .01
-
Factors Influencing the Efficiency of In Vitro Embryo Production in the Pig
한국동물번식학회지
2015 .01
-
Structural Changes of Zona Pellucida Surface of Immature, In vivo and In vitro Matured Canine Oocytes Using Scanning Electron Microscopy
한국수정란이식학회지
2018 .01
-
Heat Stress가 소 난자의 체외성숙과 배반포 발달에 미치는 영향
한국수정란이식학회지
2017 .01
-
Changes of Ganglioside GM3 Expression in Porcine Oocyte Maturation and Early Embryonic Development In Vitro
한국수정란이식학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0