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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 615 - 628 (14page)
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초록· 키워드
오류제보하기
Preserved egg, a kind of alkaline-fermented food, is a traditional egg product in China. Here, we investigated the nutritional functions of preserved eggs by in vivo and in vitro experiments. The results of in vivo studies showed that the levels of triglycerides (TG), total cholesterol (TCHO) and low-density lipoprotein cholesterol/high density lipoprotein cholesterol (LDL-C/HDL-C) were significantly decreased (p<0.05) in the liver of rats treated with preserved eggs. Meanwhile, the levels of two important cancer markers, interleukin-6 (IL-6) and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), were also significantly decreased (p<0.05) in treated rats. In vitro studies were performed on Caco-2 cells, a human epithelial colorectal adenocarcinoma cell line. It demonstrated that the gastrointestinal (GI) digests of preserved eggs significantly accelerated (p<0.05) the apoptosis by upregulating caspase-3 in the Caco-2 cells. Besides, after treated with preserved eggs, the half maximal inhibitory concentration (IC50) of preserved eggs digests to Caco-2 cells was 5.75 mg/mL, indicating the significant inhibition of cell proliferation provided by preserved eggs (p<0.05). The results shown in this study demonstrated that preserved eggs may be a novel functional food involved with antilipemic, anti-inflammatory activity as well as the effect on accelarating the apoptosis of Caco-2 cells.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Arends MJ / 1990 / Apoptosis. The role of the endonuclease / Am J Pathol 136:593~608
Baigent C / 2005 / Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins / Lancet 366:1267~1278
Bhattacharjee A / 2001 / Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses / Proc Natl Acad Sci USA 98:13790~13795
Bonnesen C / 2001 / Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines / Cancer research 61:6120~6130
Bortner CD / 1995 / The role of DNA fragmentation in apoptosis / Trends in Cell Biology 5:21~26
Baigent C / 2005 / Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins / Lancet 366:1267~1278
Bhattacharjee A / 2001 / Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses / Proc Natl Acad Sci USA 98:13790~13795
Bonnesen C / 2001 / Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines / Cancer research 61:6120~6130
Bortner CD / 1995 / The role of DNA fragmentation in apoptosis / Trends in Cell Biology 5:21~26
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