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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives Adrenergic alpha 1 and 2 receptors work as pathways to control the serotonergic neuron moderation and mirtazapine acts as antagonist of these receptors. The adrenoreceptor alpha 1a (ADRA1A) gene, which encodes adrenergic alpha 1 receptor, has Arg-347Cys genetic polymorphism and the polymorphism has strong relationship with many neuro-psychiatric diseases. In this study, we explored the relationship between ADRA1A R347C polymorphism and mirtazapine treatment response in Koreans with major depression. Methods 352 patients enrolled in this study, and the symptoms were evaluated by 17-item Hamilton Depression Rating (HAMD-17) scale. After 1, 2, 4, 8, and 12 weeks of mirtazapine treatment, the association between ADRA1A R347C polymorphism and remission/response outcomes was evaluated. Results Treatment response to mirtazapine was significantly better in T allele carriers than C allele homozygotes after 12 weeks of mirtazapine monotherapy. The percentile decline of HAMD-17 score in T allele carriers was larger than that of C allele homozygotes. ADRA1A R347C genotypes were not significantly associated with remission. Conclusions The result showed that treatment response to mirtazapine was significantly associated with ADRA1A R347C genetic polymorphism. T allele carriers showed better treatment response than C allele homozygotes. It can be supposed that T allele carriers have a trend of better treatment response to mirtazapine monotherapy.
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참고문헌 (31)
참고문헌 신청
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Duffy A / 2000 / The implications of genetics studies of major mood disorders for clinical practice / J Clin Psychiatry 61:630~637
Fava M / 2003 / The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression / J Clin Psychiatry 64(Suppl 13):26~29
Fabbri C / 2013 / Pharmacogenetics of antidepressant drugs: an update after almost 20 years of research / Am J Med Genet B Neuropsychiatr Genet 162B:487~520
Stone EA / 2003 / Emerging evidence for a central epinephrine-innervated alpha 1-adrenergic system that regulates behavioral activation and is impaired in depression / Neuropsychopharmacology 28:1387~1399
Duffy A / 2000 / The implications of genetics studies of major mood disorders for clinical practice / J Clin Psychiatry 61:630~637
Fava M / 2003 / The role of the serotonergic and noradrenergic neurotransmitter systems in the treatment of psychological and physical symptoms of depression / J Clin Psychiatry 64(Suppl 13):26~29
Fabbri C / 2013 / Pharmacogenetics of antidepressant drugs: an update after almost 20 years of research / Am J Med Genet B Neuropsychiatr Genet 162B:487~520
Stone EA / 2003 / Emerging evidence for a central epinephrine-innervated alpha 1-adrenergic system that regulates behavioral activation and is impaired in depression / Neuropsychopharmacology 28:1387~1399
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