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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder (MDD) patients. Methods We enrolled 422 patients in this study. Symptoms were evaluated using the 21-item Hamilton Depression Rating (HAMD-21) Scale. After 1, 2, 4, and 8 weeks of mirtazapine treatment, the association between the Alu I/D polymorphism in the tPA gene and remission/response outcomes were evaluated. Results The proportion of I/I homozygotes in responders was higher than that in non-responders, whereas the proportion of D/D homozygotes in responders was lower than that in non-responders at 8 weeks of treatment (p = 0.032, OR = 1.57). The percentage decline of HAMD-21 scores in I allele carriers was larger than that of D/D homozygotes at 2 and 8 weeks of treatment (p = 0.035 and 0.007, respectively). I allele carriers were associated with remission at 8 weeks of treatment (p = 0.047, OR = 2.2). Conclusions These results show that treatment response and remission to mirtazapine were associated with the Alu I/D polymorphism of the tPA gene. This suggests the Alu I/D polymorphism may be a potential genetic marker for the prediction of therapeutic response to mirtazapine treatment in patients with MDD.
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참고문헌 (48)
참고문헌 신청
Jones KR / 1990 / Molecular cloning of a human gene that is a member of the nerve growth factor family / Proc Natl Acad Sci U S A 87:8060~8064
Leibrock J / 1989 / Molecular cloning and expression of brain-derived neurotrophic factor / Nature 341:149~152
Ventimiglia R / 1995 / The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro / Eur J Neurosci 7:213~222
Fernandes BS / 2014 / Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis / Mol Psychiatry 19:750~751
Polyakova M / 2015 / BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis / J Affect Disord 174:432~440
Leibrock J / 1989 / Molecular cloning and expression of brain-derived neurotrophic factor / Nature 341:149~152
Ventimiglia R / 1995 / The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro / Eur J Neurosci 7:213~222
Fernandes BS / 2014 / Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis / Mol Psychiatry 19:750~751
Polyakova M / 2015 / BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis / J Affect Disord 174:432~440
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