Effect of Neem (Azadirachta indica) oil on the progressive growth of a spontaneous T cell lymphoma

Mallick, Sanjaya Kumar; Gupta, Vivekanand; Singh, Mahendra Pal; Vishvakarma, Naveen Kumar; Singh, Nisha; Singh, Sukh Mahendra

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자료유형: 학술저널

저자정보: Mallick, Sanjaya Kumar (School of Biotechnology, Banaras Hindu University) Gupta, Vivekanand (School of Biotechnology, Banaras Hindu University) Singh, Mahendra Pal (School of Biotechnology, Banaras Hindu University) Vishvakarma, Naveen Kumar (School of Biotechnology, Banaras Hindu University) Singh, Nisha (School of Biotechnology, Banaras Hindu University) Singh, Sukh Mahendra (School of Biotechnology, Banaras Hindu University)

저널정보: 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제7권 제5호

발행연도: 2008.1

수록면: 459 - 465 (7page)

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The present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumor-associated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumor-bearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.

#Neem oil #Tumor growth #Tumor-associated macrophages

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